Review
Copyright ©The Author(s) 2016.
World J Virol. Aug 12, 2016; 5(3): 87-96
Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.87
Table 1 Overview of host restriction factors for human cytomegalovirus
Host restriction factors PYHIN familyRegulationCMV inhibitionHCMV counter measureRef.
IFI16Type I IFN inducibleHCMV-DNA sensing in the nucleusSequestration by HCMV pp65 for MIEP activation[42,43,46,60,72]
Interaction with HCMV pp65 to inhibit UL54 promoterProtection from proteasome degradation by pp65
Antiviral cytokine expressionDelocalization upon phosphorylation by HCMV UL97
AIM2Type I IFN inducibleMCMV-DNA sensing in the cytoplasmNot known[66]
Inflammasome activation
ND10 family
PMLCell cycle dependentTranscriptionally inactive chromatin state of MIEP inductionTargeting HCMV IE1 for degradation hDaxx binding by pp71 for proteasome degradation[93-116]
hDaxx
Sp100
KDMsCell cycle dependentInhibition of HCMV latencyPrevention of KDM association with the MIEP by HCMV UL138[117]