Copyright
©The Author(s) 2016.
World J Virol. Aug 12, 2016; 5(3): 87-96
Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.87
Published online Aug 12, 2016. doi: 10.5501/wjv.v5.i3.87
Host restriction factors PYHIN family | Regulation | CMV inhibition | HCMV counter measure | Ref. |
IFI16 | Type I IFN inducible | HCMV-DNA sensing in the nucleus | Sequestration by HCMV pp65 for MIEP activation | [42,43,46,60,72] |
Interaction with HCMV pp65 to inhibit UL54 promoter | Protection from proteasome degradation by pp65 | |||
Antiviral cytokine expression | Delocalization upon phosphorylation by HCMV UL97 | |||
AIM2 | Type I IFN inducible | MCMV-DNA sensing in the cytoplasm | Not known | [66] |
Inflammasome activation | ||||
ND10 family | ||||
PML | Cell cycle dependent | Transcriptionally inactive chromatin state of MIEP induction | Targeting HCMV IE1 for degradation hDaxx binding by pp71 for proteasome degradation | [93-116] |
hDaxx | ||||
Sp100 | ||||
KDMs | Cell cycle dependent | Inhibition of HCMV latency | Prevention of KDM association with the MIEP by HCMV UL138 | [117] |
- Citation: Landolfo S, De Andrea M, Dell’Oste V, Gugliesi F. Intrinsic host restriction factors of human cytomegalovirus replication and mechanisms of viral escape. World J Virol 2016; 5(3): 87-96
- URL: https://www.wjgnet.com/2220-3249/full/v5/i3/87.htm
- DOI: https://dx.doi.org/10.5501/wjv.v5.i3.87