Plant-based vaccines against viral hepatitis: A panoptic review

Table 1 Landmark events in the development of hepatitis B and hepatitis C plant-based vaccines

Virus	Plant species	Antigen	Platforms used	Ref.
Hepatitis B	Tobacco	Surface antigen	Transformation	Mason et al[46]
	Lettuce, lupin	Surface antigen	Expression	Kapusta et al[47]
	Potato	Surface antigen	Genetic engineering	Kong et al[48]
	Banana	Surface antigen	Expression	Kumar et al[49]
Hepatitis C	Tobacco	Sequence HVR1 from E2 protein	Codon optimization	Piazzolla et al[50]
Hepatitis E	Tomato	ORF 2 partial gene	Agroinfiltration	Ma et al[51]
	Potato	Capsid protein	Genetic engineering	Maloney et al[52]

HVR1: Hypervariable region 1; E2: Envelope protein 2; ORF: Open reading frame.