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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Identification of various cell culture models for the study of Zika virus
Kiyoshi Himmelsbach, Eberhard Hildt, Department of Virology, Paul-Ehrlich-Institut, Langen 63225, Germany
Eberhard Hildt, Center for Infection Research (DZIF), Braunschweig 38124, Germany
Author contributions: Himmelsbach K designed and performed the experiments, analyzed the data and wrote the manuscript; Hildt E coordinated the research, analyzed the data and edited the manuscript.
Supported by the Federal Ministry of Health (BMG) to Hildt E.
Conflict-of-interest statement: There are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eberhard Hildt, PhD, Professor, Department of Virology, Paul-Ehrlich-Institut, Paul-Ehrlich-Str. 51-59, Langen 63225, Germany. eberhard.hildt@pei.de
Telephone: +49-610-3775411 Fax: +49-610-3771273
Received: October 25, 2017
Peer-review started: October 27, 2017
First decision: November 23, 2017
Revised: December 6, 2017
Accepted: December 13, 2017
Article in press: December 13, 2017
Published online: February 12, 2018
Processing time: 104 Days and 22.6 Hours
Peer-review started: October 27, 2017
First decision: November 23, 2017
Revised: December 6, 2017
Accepted: December 13, 2017
Article in press: December 13, 2017
Published online: February 12, 2018
Processing time: 104 Days and 22.6 Hours
Core Tip
Core tip: In this study ten different cell lines, human and non-human, from various tissues (e.g., hepatocytes, keratinocytes and neuronal cells) were tested upon their susceptibility to Zika virus (ZIKV) infection. Except CHO cells all cells supported ZIKV life cycle, but differed in parts strongly in the intracellular and released amount of infectious viral particles. Investigating the interferon response showed no clear correlation between high and low producer cell lines.