Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Inflammatory and oxidative stress in rotavirus infection
Carlos A Guerrero, Orlando Acosta, Department of Physiological Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111311, Colombia
Author contributions: Both authors contributed equally to critically reading, analyzing and writing the manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Carlos A Guerrero, MD, MSc, PhD, Professor of Medicine, Department of Physiological Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Carrera 45 # 26-85, Bogotá 111311, Colombia. caguerrerof@unal.edu.co
Telephone: +57-1-3165000 Fax: +57-1-3165000
Received: August 12, 2015
Peer-review started: August 13, 2015
First decision: September 28, 2015
Revised: December 2, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 12, 2016
Processing time: 268 Days and 13.2 Hours
Peer-review started: August 13, 2015
First decision: September 28, 2015
Revised: December 2, 2015
Accepted: January 27, 2016
Article in press: January 29, 2016
Published online: May 12, 2016
Processing time: 268 Days and 13.2 Hours
Core Tip
Core tip: Rotavirus entry into the host cell requires cell surface molecules providing binding, chaperoning and oxido-reducing functions. Sialic acid/integrin α2β1, heat shock cognate protein 70 and protein disulfide isomerase (PDI) seem to perform these functions. Recently, the cell surface oxido-reduction activity based at least on PDI has been highlighted as a potential determinant of the conformational changes that are required by viral structural proteins in order to facilitate virus entry. The rotavirus-induced oxidative stress and inflammatory signaling is an attractive target for therapeutic intervention as antioxidant and anti-inflammatory treatment has proved to efficiently inhibit rotavirus infection.