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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virology. Aug 12, 2015; 4(3): 303-312
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.303
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.303
Associations among depression, suicidal behavior, and quality of life in patients with human immunodeficiency virus
Gianluca Serafini, Mario Amore, Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy
Franco Montebovi, Denise Erbuto, Paolo Girardi, Maurizio Pompili, Department of Neurosciences, Suicide Prevention Center, Sant’Andrea Hospital, 00189 Rome, Italy
Dorian A Lamis, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30303, United States
Author contributions: Serafini G and Pompili M contributed in reviewing the literature and drafting the paper; Amore M and Girardi P provided the intellectual impetuous and supervised the search strategy; Montebovi F, Erbuto D and Lamis DA provided help in selecting papers and drafting the papers; this research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Conflict-of-interest statement: The authors declare no conflict of interests.
Data sharing statement: We believe that we do not include any data sharing statement since this is not a basic research nor a clinical research study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Maurizio Pompili, MD, PhD, Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant’Andrea Hospital 1039, Via di Grottarossa, 1035, 00189 Rome, Italy. maurizio.pompili@uniroma1.it
Telephone: +39-06-33775675 Fax: +39-06-33775342
Received: February 28, 2015
Peer-review started: March 2, 2015
First decision: May 14, 2015
Revised: May 25, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 12, 2015
Peer-review started: March 2, 2015
First decision: May 14, 2015
Revised: May 25, 2015
Accepted: July 29, 2015
Article in press: August 3, 2015
Published online: August 12, 2015
Core Tip
Core tip: Among patients with human immunodeficiency virus (HIV) the prevalence of major depressive disorder (MDD), suicidal ideation, and attempted suicides ranged from 14.0% to 27.2%, from 13.6% to 31.0%, and from 3.9% to 32.7%, respectively. Multiple risk factors for both depression and suicide were identified in HIV patients. Importantly, a consistent association has been reported between MDD, suicidal ideation, and poor quality of life in individuals living with HIV. The early detection and adequate treatment of depressive symptoms and suicidality should be considered fundamental tasks when managing HIV infected patients, particularly in those individuals who are severely medically ill.