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World J Virology. Aug 12, 2015; 4(3): 285-294
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.285
Purinergic signaling and human immunodeficiency virus/acquired immune deficiency syndrome: From viral entry to therapy
Daniela F Passos, Maria Rosa C Schetinger, Daniela BR Leal
Daniela F Passos, Daniela BR Leal, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
Maria Rosa C Schetinger, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
Author contributions: Passos DF, Schetinger MRC and Leal DBR solely contributed to this paper.
Conflict-of-interest statement: We declare that we have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daniela BR Leal, PhD, Departamento de Microbiologia e Parasitologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, Santa Maria, RS 97105-900, Brazil. daniela.leal@ufsm.br
Telephone: + 55-55-32209581 Fax: + 55-55-32208242
Received: October 29, 2014
Peer-review started: October 29, 2014
First decision: December 12, 2014
Revised: July 21, 2015
Accepted: August 4, 2015
Article in press: August 7, 2015
Published online: August 12, 2015
Core Tip

Core tip: This paper reviews the latest findings regarding the involvement of the purinergic signaling system and human immunodeficiency virus (HIV) infection. On the last 10 years, several studies have been published on the participation of purinergic signaling in HIV infection. The findings helped to elucidate disease mechanisms and proposed new targets and approaches to therapy. We have found that basic and clinical research on this field are very promising and must be further pursued.