Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virology. Aug 12, 2015; 4(3): 198-208
Published online Aug 12, 2015. doi: 10.5501/wjv.v4.i3.198
Pharmacogenetics as a tool to tailor antiretroviral therapy: A review
Antonio Aceti, Laura Gianserra, Lara Lambiase, Alfredo Pennica, Elisabetta Teti
Antonio Aceti, Laura Gianserra, Lara Lambiase, Alfredo Pennica, Elisabetta Teti, Clinical Infectious Diseases, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest statement: The authors declare that there is no actual or potential conflict of interest in relation to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Antonio Aceti, Professor, Clinical Infectious Diseases, Sant’Andrea Hospital, Sapienza University of Rome, via Grottarossa 1035-1039, 00189 Rome, Italy. antonio.aceti@uniroma1.it
Telephone: +39-06-33775817 Fax: +39-06-33775073
Received: September 27, 2014
Peer-review started: September 28, 2014
First decision: December 17, 2014
Revised: July 8, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: August 12, 2015
Processing time: 319 Days and 10.9 Hours
Core Tip

Core tip: The wide availability of drugs and therapeutic regimens for the human immunodeficiency virus infection treatment and the presence of associated adverse effects related to interindividual variability leads the clinician to look for an individualized therapy as much as possible. Pharmacogenetics can provide useful tools for this purpose and can propose models of genetics tests that, however, need to be further studied. This paper aim is to provide a critical and understandable review of published literature and a guidance about future prospects in this field.