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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2025; 14(1): 99923
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.99923
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.99923
Septic shock due to cytomegalovirus colitis associated with rituximab use: A case report
Siddharth Patel, Mrudula Thiriveedi, Department of Internal Medicine, Decatur Morgan Hospital, Decatur, AL 35601, United States
Jordan Jay, Department of Medicine, Alabama College of Osteopathic Medicine, Dothan, AL 36303, United States
Prutha Pathak, Department of Internal Medicine, North Alabama Medical Center, Florence, AL 35630, United States
Mc Anto Antony, Department of Endocrinology, Diabetes and Metabolism, Medical University of South Carolina/AnMed Campus, Anderson, SC 29621, United States
Author contributions: Patel S and Jay J contributed to manuscript writing, editing, and data collection; Pathak P, Antony MA, and Thiriveedi M contributed to conceptualization and supervision; all authors have read and approved the final manuscript.
Informed consent statement: Informed verbal consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Siddharth Patel, MBBS, Attending Doctor, Director, Department of Internal Medicine, Decatur Morgan Hospital, 1201 7th Street SE, Decatur, AL 35601, United States. sidd8801@gmail.com
Received: August 3, 2024
Revised: September 27, 2024
Accepted: October 29, 2024
Published online: March 25, 2025
Processing time: 116 Days and 6.6 Hours
Revised: September 27, 2024
Accepted: October 29, 2024
Published online: March 25, 2025
Processing time: 116 Days and 6.6 Hours
Core Tip
Core Tip: With the increasing use of biologics in medicine, there has been an emergence of opportunistic infections. Cytomegalovirus (CMV) infections remain asymptomatic or cause only mild symptoms in most immunocompetent adults. However, it can cause infectious complications in immunocompromised individuals-especially those with defective T-lymphocyte function. Rituximab (RTX) use is associated with B-lymphocyte depletion and increased risk of infections. However, CMV infections after long-term RTX are uncommon. Our case describes septic shock due to CMV colitis associated with RTX use which is an extremely rare entity. It highlights the need for consideration of rare opportunistic infections in all patients on biologics.