Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2025; 14(1): 97482
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.97482
Rising incidence of acute hepatitis A among adults and clinical characteristics in a tertiary care center of Pakistan
Yumna Shahid, Amna Subhan Butt, Iqra Jamali, Faisal Wasim Ismail
Yumna Shahid, Division of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
Amna Subhan Butt, Iqra Jamali, Faisal Wasim Ismail, Department of Medicine, Aga Khan University Hospital, Karachi 74800, Pakistan
Co-corresponding authors: Amna Subhan Butt and Faisal Wasim Ismail.
Author contributions: Shahid Y contributed to the design of the study, acquisition of the data, and analysis and writing of the final manuscript; Butt AS contributed to the study conception and design, data analysis and interpretation, reviewed the final manuscript, and made corrections to the manuscript; Jamali I helped retrieve patient data, entry, and analysis; Ismail FW reviewed the study and designed the manuscript; All of the authors read and approved the final version of the manuscript to be published.
Institutional review board statement: Ethics approval was obtained from Ethics Review Committee Aga Khan University Pakistan, No. 2024-9479-28215.
Informed consent statement: Informed consent was not required by the ethics review board since the methodology involved review of patient charts.
Conflict-of-interest statement: The authors have no conflicts to interest to declare.
Data sharing statement: Data files can be accessed by reasonable request to the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/.
Corresponding author: Amna Subhan Butt, FCPS, MBBS, MSc, Associate Professor, Department of Medicine, Aga Khan University Hospital, Stadium Road, Karachi 74800, Pakistan. amna.subhan@aku.edu
Received: May 31, 2024
Revised: August 29, 2024
Accepted: October 15, 2024
Published online: March 25, 2025
Processing time: 180 Days and 8.7 Hours
Core Tip

Core Tip: In recent years, there has been a notable shift in the prevalence of viruses causing acute hepatitis. The hepatitis A virus (HAV) is increasingly affecting adults, contrary to its previous predominance among children, while the incidence of hepatitis E virus (HEV) among adults appears to remain unchanged. This change highlights a significant epidemiological transition. Although cases of HEV infection are associated with higher mortality rates, acute liver failure, and coagulopathy compared to those of HAV, signaling distinct impacts between the two viruses in adult populations.