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World J Virol. Mar 25, 2025; 14(1): 100003
Published online Mar 25, 2025. doi: 10.5501/wjv.v14.i1.100003
Crimean-Congo hemorrhagic fever: Pathogenesis, transmission and public health challenges
Sita Kumari Karanam, Kandra Nagvishnu, Praveen Kumar Uppala, Sandhya Edhi, Srinivasa Rao Varri
Sita Kumari Karanam, Department of Pharmaceutical Biotechnology, Maharajah’s College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Kandra Nagvishnu, Department of Pharmacology, Santhiram Medical College and General Hospital, Nandyal 518501, Andhra Pradesh, India
Praveen Kumar Uppala, Department of Pharmacology, Maharajah's College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Sandhya Edhi, Department of Pharmacy, Maharajah's College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Srinivasa Rao Varri, Department of Pharmaceutical Analysis, Maharajah's College of Pharmacy, Vizianagaram 535002, Andhra Pradesh, India
Author contributions: Karanam SK was responsible for drafting the article or revising it critically for important intellectual content and manuscript final review; Nagvishnu K was responsible for concept, acquisition of the data, and analysis interpretation of the data; Uppala PK was responsible for design of the study, the conception, preparation of final manuscript; Edhi S was responsible for design of the study acquisition of the data, and analysis; Varri SR was responsible for literature search, acquisition of the data, and analysis; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest regarding the publication of this manuscript. All authors have contributed to this work based solely on scientific and academic merit, without any influence from commercial, personal, political, intellectual, or religious interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Praveen Kumar Uppala, PhD, Assistant Professor, Research Fellow, Department of Pharmacology, Maharajah's College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, India. praveen.chintu32@gmail.com
Received: August 5, 2024
Revised: October 11, 2024
Accepted: November 5, 2024
Published online: March 25, 2025
Processing time: 114 Days and 20.7 Hours
Core Tip

Core Tip: This review provides a comprehensive overview of Crimean-Congo hemorrhagic fever (CCHF), a severe tick-borne viral disease with significant public health implications. The article discusses the virus's transmission dynamics, clinical manifestations, current diagnostic techniques, and available treatments, including the use of antiviral therapy. It emphasizes the urgent need for vaccine development, better diagnostic tools, and efficient therapies. By addressing gaps in knowledge and highlighting the importance of a one health approach, this review serves as a critical resource for researchers and healthcare professionals seeking to improve CCHF control and prevention strategies.