Juneja D, Jain R, Nasa P. Dengue induced acute liver failure: A meta summary of case reports. World J Virol 2024; 13(1): 91457 [PMID: 38616857 DOI: 10.5501/wjv.v13.i1.91457]
Corresponding Author of This Article
Prashant Nasa, MD, Chief Doctor, Department of Critical Care Medicine, NMC Specialty Hospital, Al Nahda 2, Amman Street, Dubai 7832, United Arab Emirates. dr.prashantnasa@gmail.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Virol. Mar 25, 2024; 13(1): 91457 Published online Mar 25, 2024. doi: 10.5501/wjv.v13.i1.91457
Dengue induced acute liver failure: A meta summary of case reports
Deven Juneja, Ravi Jain, Prashant Nasa
Deven Juneja, Department of Critical Care Medicine, Max Super Speciality Hospital, New Delhi 110017, India
Ravi Jain, Department of Critical Care Medicine, Mahatma Gandhi Medical College and Hospital, Jaipur 302022, Rajasthan, India
Prashant Nasa, Department of Critical Care Medicine, NMC Specialty Hospital, Dubai 7832, United Arab Emirates
Author contributions: Nasa P acquisition of data, analysis and interpretation of data, drafting the article, final approval; Juneja D acquisition of data, analysis and interpretation of data, drafting the article, final approval; Jain R interpretation of data, revising the article, final approval.
Conflict-of-interest statement: All authors declare no conflict-of-interest related to this work.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prashant Nasa, MD, Chief Doctor, Department of Critical Care Medicine, NMC Specialty Hospital, Al Nahda 2, Amman Street, Dubai 7832, United Arab Emirates. dr.prashantnasa@gmail.com
Received: December 28, 2023 Peer-review started: December 28, 2023 First decision: January 16, 2024 Revised: January 19, 2024 Accepted: February 20, 2024 Article in press: February 20, 2024 Published online: March 25, 2024 Processing time: 73 Days and 19.7 Hours
Core Tip
Core Tip: Dengue infection frequently affects liver function but, in most cases, it exhibits transient and mild increase of transaminases. Rarely, it may lead to severe liver injury and development of acute liver failure (ALF). As there is no specific therapy, most of these patients are managed conservatively and provided with organ support. N-acetyl cysteine is increasingly been used in the management of non-paracetamol induced ALF. However, its utility in ALF secondary to dengue is still limited to small case series and case reports. Even liver transplantation has been rarely attempted in these patients because of high incidence of underlying multi-organ failure and increased risk of bleeding. However, clinical outcomes in these patients may be improved with early recognition and timely supportive care.
