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World J Virol. Sep 25, 2022; 11(5): 237-251
Published online Sep 25, 2022. doi: 10.5501/wjv.v11.i5.237
Association of COVID-19 with hepatic metabolic dysfunction
Ramesh Kumar, Vijay Kumar, Rahul Arya, Utpal Anand, Rajeev Nayan Priyadarshi
Ramesh Kumar, Rahul Arya, Department of Gastroenterology, All India Institute of Medical Sciences, Patna, Patna 801507, Bihar, India
Vijay Kumar, Department of Medicine, All India Institute of Medical Sciences, Patna, Patna 801507, Bihar, India
Utpal Anand, Department of Surgical Gastroenterology, All India Institute of Medical Sciences, Patna, Patna 801507, Bihar, India
Rajeev Nayan Priyadarshi, Department of Radiodiagnosis, All India Institute of Medical Sciences, Patna, Patna 801507, Bihar, India
Author contributions: Kumar R, Kumar V, and Arya R contributed in concept and design of manuscript, data collection and manuscript writing; Anand U and Priyadarshi RN contributed in data collection, critical inputs and manuscript revision.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramesh Kumar, MD, Associate Professor, Department of Gastro-enterology, All India Institute of Medical Sciences, Phulwari Sharif, Patna 801507, Bihar, India. docrameshkr@gmail.com
Received: March 13, 2022
Peer-review started: March 13, 2022
First decision: April 13, 2022
Revised: April 25, 2022
Accepted: June 20, 2022
Article in press: June 20, 2022
Published online: September 25, 2022
Processing time: 195 Days and 0.9 Hours
Core Tip

Core Tip: In coronavirus disease 2019 (COVID-19) patients, the virus induces a complex viral-host interaction that leads to metabolic reprogramming, altered immunological responses, and a variety of clinical consequences. In metabolomic and lipidomic studies, a variety of alterations in amino acids, lipids, carbohydrates, and energy metabolism have been identified in such patients. The liver is the primary metabolic organ; thus, these metabolic alterations may have a major impact on patients with liver diseases and metabolic comorbidities that are common in COVID-19 patients. Therefore, this review article discusses the pathophysiological aspects and clinical implications of metabolic dysfunction in COVID-19 patients with a focus on the liver.