Systematic Reviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Jun 25, 2024; 13(2): 92586
Published online Jun 25, 2024. doi: 10.5501/wjv.v13.i2.92586
Exploring the impact of rotavirus vaccination on antibiotic prescription and resistance: A comprehensive systematic review
Lakshmi Venkata Simhachalam Kutikuppala, Matei-Alexandru Cozma, Gautam Maddineni, Harshal Prakash Chorya, Nayanika Tummala, Swathi Godugu, Jyothi Swaroop Chintala, Mihnea-Alexandru Găman
Lakshmi Venkata Simhachalam Kutikuppala, Department of General Surgery, Dr NTR University of Health Sciences, Vijayawada 520008, Andhra Pradesh, India
Matei-Alexandru Cozma, Mihnea-Alexandru Găman, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest 050474, Romania
Matei-Alexandru Cozma, Department of Gastroenterology, Colentina Clinical Hospital, Bucharest 020125, Romania
Gautam Maddineni, Department of Internal Medicine, Florida State University, Cape Coral, FL 33909, United States
Harshal Prakash Chorya, Department of Internal Medicine, Baroda Medical College, Vadodara 390001, Gujarat, India
Nayanika Tummala, Department of Internal Medicine, GITAM Institute of Medical Sciences and Research (GIMSR), Visakhapatnam 530045, Andhra Pradesh, India
Swathi Godugu, Department of Internal Medicine, Zaporozhye State Medical University, Zaporozhye 69000, Ukraine
Jyothi Swaroop Chintala, Department of Anesthesiology, Dr NTR University of Health Sciences, Vijayawada 520008, Andhra Pradesh, India
Mihnea-Alexandru Găman, Department of Hematology, Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest 022328, Romania
Author contributions: Simhachalam Kutikuppala LV, Cozma MA, Maddineni G, Chorya HP, Tummala N, Godugu S, Chintala JS, and Găman MA have contributed to conceptualization, methodology, validation, formal analysis, investigation, writing original draft preparation, writing review and editing; Simhachalam Kutikuppala LV and Găman MA contributed to supervision; All authors have read and agreed to the published version of the manuscript.
Conflict-of-interest statement: None to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mihnea-Alexandru Găman, Doctor, MD, PhD, Doctor, Research Fellow, Researcher, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, No. 8 Eroii Sanitari Boulevard, Bucharest 050474, Romania. mihneagaman@yahoo.com
Received: January 30, 2024
Revised: May 18, 2024
Accepted: June 7, 2024
Published online: June 25, 2024
Processing time: 145 Days and 20.4 Hours
Abstract
BACKGROUND

Rotavirus is a highly contagious virus responsible for a significant burden of acute gastroenteritis, particularly among infants and young children worldwide, however, vaccination against this viral agent is available. Several studies have hypothesized that rotavirus vaccination has been linked to lower rates of antibiotic resistance.

AIM

To assess the relationship between rotavirus vaccination and antibiotic resistance.

METHODS

The present systematic review was tailored based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. Several electronic databases (PubMed/MEDLINE, Scopus and Web of Science) were searched independently by two investigators in order to retrieve relevant publications published until April 2023 that investigated the aforementioned research question.

RESULTS

The comprehensive database search identified a total of 91 records. After the duplicates were removed (n = 75), we screened the titles and abstracts of 16 potentially eligible publications. After the irrelevant records were excluded (n = 5), we screened the full texts of 11 manuscripts. Finally, 5 studies were entered into the qualitative and quantitative analysis.

CONCLUSION

In conclusion, all the studies support the idea that vaccinations can reduce the need for antibiotic prescriptions which could potentially contribute to mitigating antibiotic resistance. However, to fully comprehend the mechanisms of antibiotic resistance, enhance treatment guidelines, and consider diverse demographic situations, further research is necessary to use evidence-based strategies to fight antibiotic misuse and resistance.

Keywords: Rotavirus; Vaccination; Gastroenteritis; Antibiotics; Antibiotic resistance; Diarrhea; Children

Core Tip: Vaccination against rotavirus has been hypothesized to reduce the need for antibiotic prescriptions. Herein, we conducted a systematic review to evaluate the relationship between antibiotic resistance and rotavirus vaccination. Our findings support the idea that vaccinations, including rotavirus vaccination, can reduce the need for antibiotic prescriptions which could potentially contribute to mitigating antibiotic resistance.