Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2022; 11(2): 111-112
Published online Mar 25, 2022. doi: 10.5501/wjv.v11.i2.111
Novel appearance of hyperglycemia/diabetes, associated with COVID-19
Ioannis Ilias
Ioannis Ilias, Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, Athens GR-11521, Greece
Author contributions: Ilias Ι conceived and wrote this letter.
Conflict-of-interest statement: The author declares no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ioannis Ilias, MD, PhD, Consultant Physician-Scientist, Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq., Athens GR-11521, Greece. iiliasmd@yahoo.com
Received: September 29, 2021
Peer-review started: September 29, 2021
First decision: January 12, 2022
Revised: January 12, 2022
Accepted: March 15, 2022
Article in press: March 15, 2022
Published online: March 25, 2022
Processing time: 173 Days and 15.3 Hours
Abstract

In a recent meta-analysis the prevalence of coronavirus disease 2019 (COVID-19)-associated hyperglycemia was 25%, and that of COVID-19-associated new-onset diabetes was 19%. An association between hyperglycemia or new-onset diabetes and COVID-19 has been suggested. In a recent relevant study of critically and non-critically ill patients with COVID-19, we found that indeed beta-cell function was compromised in critically ill patients with COVID-19 and that these patients showed a high glycemic gap. Nevertheless, one quarter of critically ill patients with no history of diabetes have stress hyperglycemia, a finding which could obscure the prevalence of hyperglycemia or new-onset diabetes that could be attributed to COVID-19 per se.

Keywords: Blood glucose, Pandemics, Severe acute respiratory syndrome coronavirus 2, Humans, Hyperglycemia, Hospitalization

Core Tip: An association between hyperglycemia or new-onset diabetes and coronavirus disease 2019 (COVID-19) has been suggested. Nevertheless, one quarter of critically ill patients with no history of diabetes have stress hyperglycemia, a finding which could obscure the prevalence of hyperglycemia or new-onset diabetes that could be attributed to COVID-19 per se.