Gato S, Lucena-Valera A, Muñoz-Hernández R, Sousa JM, Romero-Gómez M, Ampuero J. Impact of COVID-19 on liver disease: From the experimental to the clinic perspective. World J Virol 2021; 10(6): 301-311 [PMID: 34909404 DOI: 10.5501/wjv.v10.i6.301]
Corresponding Author of This Article
Javier Ampuero, MD, MSc, PhD, Doctor, Professor, Senior Scientist, Digestive Department, Hospital Universitario Virgen del Rocio, Avda. Manuel Siurot s/n, Sevilla 41013, Spain. javi.ampuero@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Virol. Nov 25, 2021; 10(6): 301-311 Published online Nov 25, 2021. doi: 10.5501/wjv.v10.i6.301
Impact of COVID-19 on liver disease: From the experimental to the clinic perspective
Sheila Gato, Ana Lucena-Valera, Rocío Muñoz-Hernández, José Manuel Sousa, Manuel Romero-Gómez, Javier Ampuero
Sheila Gato, Rocío Muñoz-Hernández, Manuel Romero-Gómez, Javier Ampuero, SeLiver Group, Instituto de Biomedicina de Sevilla, Sevilla 41013, Spain
Ana Lucena-Valera, José Manuel Sousa, Manuel Romero-Gómez, Javier Ampuero, Digestive Department, Hospital Universitario Virgen del Rocio, Sevilla 41013, Spain
Rocío Muñoz-Hernández, Manuel Romero-Gómez, Javier Ampuero, University of Seville, Sevilla 41013, Spain
Author contributions: Ampuero J conceived and designed the review; Muñoz-Hernández R, and Sousa JM collected data from the literature; Gato S, and Lucena-Valera A drafted the manuscript; Ampuero J and Romero-Gómez MR critically revised the manuscript.
Conflict-of-interest statement: No conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Javier Ampuero, MD, MSc, PhD, Doctor, Professor, Senior Scientist, Digestive Department, Hospital Universitario Virgen del Rocio, Avda. Manuel Siurot s/n, Sevilla 41013, Spain. javi.ampuero@gmail.com
Received: March 24, 2021 Peer-review started: March 24, 2021 First decision: May 5, 2021 Revised: May 18, 2021 Accepted: August 13, 2021 Article in press: August 13, 2021 Published online: November 25, 2021 Processing time: 242 Days and 11.3 Hours
Abstract
Coronavirus disease 2019 (COVID-19) has caused a global pandemic unprecedented in over a century. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a predominantly respiratory infection, various degrees of liver function abnormalities have been reported. Pre-existing liver disease in patients with SARS-CoV-2 infection has not been comprehensively evaluated in most studies, but it can critically compromise survival and trigger hepatic decompensation. The collapse of the healthcare services has negatively impacted the diagnosis, monitoring, and treatment of liver diseases in non-COVID-19 patients. In this review, we aim to discuss the impact of COVID-19 on liver disease from the experimental to the clinic perspective.
Core Tip: The outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a critical threat to global public health. Beyond the respiratory symptoms, some patients with COVID-19 show liver damage. In this scenario, it has been suggested that there might be a specific relationship between SARS-CoV-2 infection and liver injury.
