Liver transplantation for hepatocellular carcinoma in Ireland: Pre-operative alpha-fetoprotein predicts tumour recurrence in a 14-year single-centre national experience

Table 1 Patient demographics

Male:female	44:13
Age, median (IQR)	59.1 (53.5-63.6)
Aetiology of HCC
Alcoholic liver disease	17 (29.8%)
Hepatitis C	17 (29.8%)
Haemochromatosis	13 (22.8%)
α-1-antitrypsin deficiency	3 (5.3%)
Primary sclerosing cholangitis	2 (3.5%)
Primary biliary cirrhosis	2 (3.5%)
Autoimmune hepatitis	2 (3.5%)
Hepatitis B	2 (3.5%)
Cryptogenic	2 (3.5%)
Cystic fibrosis	1 (1.8%)
Sarcoidosis	1 (1.8%)
Nash	1 (1.8%)
Pre-operative α-fetoprotein, median (IQR)	8.8 (3.3-29.2)
Compliant with Milan criteria	41 (71.9%)
Compliant with UCSF criteria	49 (86.0%)
Largest lesion, median (IQR)	3 (2.5-4.5)
Cirrhosis	53 (93.0%)
Steatosis	2 (3.5%)
Multifocal lesions	24 (42.1%)
Micro-vascular invasion	24 (42.1%)
Tumour differentiation
Well	24 (42.1%)
Moderate	28 (49.1%)
Poor	5 (8.8%)
Incidental lesions	5 (8.8%)

HCC: Hepatocellular carcinoma; UCSF: University of California San Francisco; IQR: Interquartile range.

Table 2 Univariate analysis of factors affecting overall survival

	HR	CI	P-value
Male sex	0.786	0.301-2.055	0.623
Age	1.001	0.954-1.051	0.952
Aetiology of HCC
Alcoholic liver disease	0.523	0.175-1.567	0.247
Hepatitis C	2.098	0.849-5.183	0.108
Haemochromatosis	0.715	0.239-2.143	0.549
Other	1.198	0.459-3.126	0.712
Pre-operative α-fetoprotein > 100 ng/mL	1.502	0.437-5.165	0.519
Compliant with Milan criteria	0.994	0.381-2.590	0.989
Compliant with UCSF criteria	0.871	0.290-2.618	0.805
Largest lesion	1.207	0.963-1.513	0.102
Cirrhosis	23.309	0.024-224.813	0.369
Steatosis	0.044	0.000-187.285	0.465
Multi-focal lesions	1.201	0.499-2.890	0.683
Micro-vascular invasion	1.489	0.619-3.578	0.374
Tumour differentiation
Well	0.862	0.349-2.131	0.748
Moderate	1.100	0.448-2.698	0.835
Poor	1.159	0.268-5.022	0.843
Incidental lesions	0.450	0.060-3.391	0.438

HCC: Hepatocellular carcinoma; UCSF: University of California San Francisco.

Table 3 Univariate analysis of factors affecting recurrence free survival

	HR	CI	P-value
Male sex	0.681	0.156-2.971	0.609
Age	1.004	0.932-1.081	0.922
Aetiology of HCC
Alcoholic liver disease	0.775	0.155-3.887	0.757
Hepatitis C	3.272	0.798-13.417	0.100
Haemochromatosis	1.210	0.243-6.024	0.816
Other	0.027	0.000-16.500	0.271
Pre-operative α-fetoprotein > 100 ng/mL	6.668	1.661-26.768	0.007
Compliant with Milan criteria	1.354	0.271-6.761	0.712
Compliant with UCSF criteria	0.739	0.148-3.692	0.712
Largest lesion	1.326	0.976-1.801	0.071
Cirrhosis	23.025	0.000-327.873	0.604
Steatosis	0.045	0.000-546.731	0.664
Multifocal lesions	2.100	0.494-8.930	0.315
Micro-vascular invasion	1.560	0.376-6.463	0.540
Tumour differentiation
Well	0.249	0.046-1.340	0.105
Moderate	1.553	0.374-6.443	0.544
Poor	5.631	1.074-29.510	0.041
Incidental lesions	0.041	0.000-720.752	0.523

HCC: Hepatocellular carcinoma; UCSF: University of California San Francisco.