Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 24, 2016; 6(2): 396-402
Published online Jun 24, 2016. doi: 10.5500/wjt.v6.i2.396
Liver transplantation for hepatocellular carcinoma in Ireland: Pre-operative alpha-fetoprotein predicts tumour recurrence in a 14-year single-centre national experience
Donal B O’Connor, John P Burke, John Hegarty, Aiden P McCormick, Niamh Nolan, Emir Hoti, Donal Maguire, Justin Geoghegan, Oscar Traynor
Donal B O’Connor, Department of Surgery, Trinity Centre for Health Sciences, Tallaght Hospital, Dublin 24, Ireland
Donal B O’Connor, John P Burke, Departments of Hepatobiliary Surgery, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
John Hegarty, Aiden P McCormick, Emir Hoti, Donal Maguire, Justin Geoghegan, Oscar Traynor, National Liver Transplant Programme, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
Niamh Nolan, Departments of Pathology, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland
Author contributions: O’Connor DB and Traynor O conceived project; O’Connor DB contributed to the preparation of manuscript and data acquisition; Burke JP contributed to statistical analysis and critical revision of manuscript; Nolan N contributed to analysis of histopathology; Hegarty J, McCormick AP, Hoti E, Maguire D, Geoghegan J and Traynor O contributed to critical revision of manuscript.
Institutional review board statement: The study was approved by the St Vincent’s University Hospital ethics review board.
Informed consent statement: Informed consent was not required for this study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Donal B O’Connor, Lecturer in Surgery, Department of Surgery, Trinity Centre for Health Sciences, Tallaght Hospital, Room 1.36, Dublin 24, Ireland. oconnd15@tcd.ie
Telephone: +353-1-4142218 Fax: +353-1-4142212
Received: November 11, 2015
Peer-review started: November 15, 2015
First decision: January 4, 2016
Revised: April 12, 2016
Accepted: May 7, 2016
Article in press: May 9, 2016
Published online: June 24, 2016
Processing time: 223 Days and 16.6 Hours
Core Tip

Core tip: We have shown good survival from a medium volume transplant centre in a small cohort of patients exceeding Milan criteria. We show an association between a pre-operative alpha-fetoprotein (AFP) > 100 and hepatocellular carcinoma (HCC) recurrence, independent of tumour size. Our study supports other single centre experience on survival after transplant for HCC with low AFP and indicates that AFP needs to be interrogated in large, multi-centre studies to see if it can be included in transplant listing criteria to augment the current radiology based dimensional criteria.