Isolated small bowel transplantation outcomes and the impact of immunosuppressants: Experience of a single transplant center

Table 1 Intraoperative data (mean ± SD, n = 77)

	Zenapax (n = 16)	Thymoglobulin (n = 22)	Campath (n = 39)	P value
Surgical time (h)	14.16 ± 2.59	12.01 ± 1.73	10.59 ± 1.59	< 0.000
Cold ischemia time (min)	514.0 ± 86.73	480.18 ± 111.60	441.0 ± 100.33	0.05
Warm ischemia time (min)	31.18 ± 5.19	30.95 ± 4.94	32.18 ± 4.62	0.636
Crystalloids (mL)	7214.67 ± 2286.39	5622.73 ± 1707.95	4705.26 ± 1791.26	0.0002
Colloids (mL)	6383.33 ± 2277.34	4428.64 ± 1611.94	3721.05 ± 1516.51	< 0.0001
Packed red cell (units)	6.47 ± 3.44	3.45 ± 1.95	3.66 ± 2.39	0.0008
Fresh frozen plasma (units)	0.73 ± 1.71	0.36 ± 1.05	1 ± 1.61	0.208
Cryoprecipitate (units)	0	0.27 ± 1.27	1.58 ± 3.32	0.377
Platelets (units)	1.20 ± 3.36	4.36 ± 8.52	3.95 ± 6.58	0.541

Table 2 Intraoperative changes in the thromboelastogram tracing (mean ± SD)

	Zenapax(n = 16)	Thymoglobulin(n = 22)	Campath(n = 39)	P value
Stage-I (baseline)
R I	9.26 ± 3.6	9.09 ± 3.88	7.36 ± 4.35	0.195
K I	2.72 ± 0.91	2.73 ± 0.97	2.21 ± 2.96	0.630
ANG I	71.64 ± 5.46	65.9 ± 14.1	66.1 ± 12.25	0.291
MA I	65.11 ± 11.1	59.53 ± 14.56	66.04 ± 13.72	0.223
Stage-II (organ on the field)
R II	9.12 ± 5.23	7.36 ± 3.17	7.15 ± 3.54	0.327
K II	4.26 ± 1.53	3.99 ± 2.1	3.10 ± 2.12	0.176
ANG II	64.25 ± 8.26	60.82 ± 11.66	55 ± 15.72	0.109
MA II	53.58 ± 10.42	53.71 ± 9.7	54.44 ± 15.16	0.974
Stage-III (reperfusion)
R III	9.3 ± 2.7	7.44 ± 2.53	7.74 ± 3.4	0.356
K III	6.13 ± 2.56	4.77 ± 2.1	3.9 ± 2.54	0.088
ANG III	56.13 ± 9.23	58.6 ± 7.36	49.2 ± 15.57	0.072
MA III	47.56 ± 12.5	50.7 ± 10.67	48.67 ± 16.1	0.855
Closing the abdominal incision (final)
R end	9.26 ± 2.58	8.77 ± 3.39	6.38 ± 2.31	0.011a
K end	6.21 ± 2.83	5.13 ± 2.1	2.79 ± 1.62	< 0.0001a
ANGe nd	56.75 ± 12.8	57.47 ± 7.6	58.1 ± 11.13	0.949
MA end	50.56 ± 8.51	51.32 ± 11.76	55.46 ± 9.23	0.339

^aP < 0.05. R: R-time (min); K: Tangential line in the thromboelastogram tracing (min); ANG: α-angle (degree); MA: Maximum amplitude (millimeter).

Table 3 Intraoperative hemodynamic data at baseline and reperfusion (mean ± SD)

	Baseline	Reperfusion	P value
Cardiac output (L/min)	7.32 ± 1.88	9.1 ± 2.62	< 0.0001
Ejection fraction (%)	38.14 ± 7.78	39.75 ± 7.76	0.183
End diastolic volume (mL)	216.24 ± 55.82	242.34 ± 64.54	< 0.0001
Mixed venous oxygen saturation	83.80 ± 3.99	85.17 ± 4.37	0.017
Heart rate (beat/min)	89.81 ± 13.49	101.41 ± 13.71	< 0.0001
Mean arterial blood pressure	77.71 ± 9.47	71.29 ± 11.64	< 0.0001
Systemic vascular resistance	793.76 ± 244.67	581.92 ± 196.8	< 0.0001
Mean pulmonary artery pressure	17.52 ± 3.82	20.17 ± 4.8	< 0.0001
Pulmonary vascular resistance	58.07 ± 26.32	52.13 ± 24.76	0.078
Pulmonary capillary wedge pressure	12.42 ± 3.44	14.82 ± 3.8	< 0.0001
Central venous pressure	9.53 ± 3.63	11.42 ± 3.46	< 0.0001