Copyright
©The Author(s) 2023.
World J Transplant. Dec 18, 2023; 13(6): 299-308
Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.299
Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.299
Figure 1 Mechanisms of action of anti-thymocyte globulin.
A: T-cell depletion in blood through complement-mediated lysis and in secondary lymphoid tissue by T cell apoptosis; B: B-cell apoptosis by anti-thymocyte globulin (ATG); C: ATG-VLA-4 complex leading to decreased adhesion proteins in endothelial cells required by leukocyte/endothelium interaction; D: Dendritic cell maturation by HLA1/ATG interaction; E: Increased natural killer T cells.
- Citation: Acharya S, Lama S, Kanigicherla DA. Anti-thymocyte globulin for treatment of T-cell-mediated allograft rejection. World J Transplant 2023; 13(6): 299-308
- URL: https://www.wjgnet.com/2220-3230/full/v13/i6/299.htm
- DOI: https://dx.doi.org/10.5500/wjt.v13.i6.299