Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2023; 13(6): 299-308
Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.299
Anti-thymocyte globulin for treatment of T-cell-mediated allograft rejection
Sumit Acharya, Suraj Lama, Durga Anil Kanigicherla
Sumit Acharya, Suraj Lama, Department of Nephrology, Shahid Dharmabhakta National Transplant Center, Bhaktapur 44800, Nepal
Durga Anil Kanigicherla, Department of Renal Medicine, Manchester University NHS Foundation Trust, Manchester M13 9WL, United Kingdom
Author contributions: Acharya S, Lama S, and Kanigicherla DA performed the necessary article search and review, analyzed the paper, and wrote the manuscript; Acharya S made the figures and tables; all the authors have read and approved the final manuscript.
Conflict-of-interest statement: All authors state that there is no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Suraj Lama, MBBS, MRes, PhD, Doctor, Department of Nephrology, Shahid Dharmabhakta National Transplant Center, Dudhpati 1, Bhaktapur, Nepal, Bhaktapur 44800, Nepal.
Received: August 20, 2023
Peer-review started: August 20, 2023
First decision: September 29, 2023
Revised: November 1, 2023
Accepted: November 17, 2023
Article in press: November 17, 2023
Published online: December 18, 2023
Core Tip

Core Tip: Anti-thymocyte globulin is a highly efficient induction agent that can prevent acute rejection and delayed graft function. It is widely used for biopsy confirmed acute rejection reversal and steroid-resistant rejection.