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World J Transplant. Jun 28, 2019; 9(2): 27-34
Published online Jun 28, 2019. doi: 10.5500/wjt.v9.i2.27
Immunometabolism: A target for the comprehension of immune response toward transplantation
Omar Domínguez-Amorocho, Tatiana Takiishi, Flavia Franco da Cunha, Niels Olsen Saraiva Camara
Omar Domínguez-Amorocho, Tatiana Takiishi, Flavia Franco da Cunha, Niels Olsen Saraiva Camara, Department of Immunology, Biomedical Sciences Institute, University of São Paulo, São Paulo 05508-900, Brazil
Author contributions: Domínguez-Amorocho O and Takiishi T contributed equally to this work, generated the figures and wrote the manuscript; da Cunha FF contributed to the writing of the manuscript; Camara NOS designed the aim of the editorial and wrote the manuscript.
Supported by FAPESP doctoral fellowship grants (Omar Dominguez-Amorocho and Flavia Cunha), No. 2017/05264-7; and PNPd postdoctoral fellowship grant (Tatiana Takiishi).
Conflict-of-interest statement: The authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Niels Olsen Saraiva Câmara, MD, PhD, Research Scientist, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1730 Cid. Universitaria, Sao Paulo 05508-000, Brazil. niels@icb.usp.br
Telephone: +55-11-30917388
Received: September 12, 2018
Peer-review started: September 12, 2018
First decision: October 5, 2018
Revised: October 25, 2018
Accepted: January 28, 2019
Article in press: January 28, 2019
Published online: June 28, 2019
Processing time: 289 Days and 9 Hours
Core Tip

Core tip: In this review we summarize the most recent findings on metabolic pathways involved in the determination of immune cell fate and highlight the relevance of understanding how metabolic reprogramming is involved in the activation of dendritic cells and T cells, as well as development of strategies that target metabolic reprogramming to counteract effector cell activation in order to prevent graft failure.