Retrospective Cohort Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplantation. Sep 10, 2018; 8(5): 167-177
Published online Sep 10, 2018. doi: 10.5500/wjt.v8.i5.167
Trends of characteristics and outcomes of donors and recipients of deceased donor liver transplantation in the United States: 1990 to 2013
Subhashini Ayloo, Sri Ram Pentakota, Michele Molinari
Subhashini Ayloo, Sri Ram Pentakota, Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ 07103, United States
Michele Molinari, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Author contributions: Ayloo S contributed to this paper with conception, design, analysis, and manuscript drafting; Pentakota SR contributed to data analysis; Molinari M contributed to data analysis and manuscript drafting.
Institutional review board statement: The study did not require approval by the ethics review board of our institution because it was conducted and reported per STROBE statement recommendations which was acknowledged in the methods section of the manuscript. This data is available to everybody and is provided by OPTN/UNOS as SRTR files.
Informed consent statement: Not applicable.
Conflict-of-interest statement: All authors report no conflict of interest.
STROBE statement: The study was reported in accordance with STROBE statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Subhashini Ayloo, MD, Associate Professor, Senior Scientist, Statistician, Surgeon, Department of Surgery, Rutgers New Jersey Medical School, 185 South Orange Avenue, MSB G586, Newark, NJ 07103, United States. ayloo.sub@rutgers.edu
Telephone: +1-973-9725874 Fax: +1-973-9723135
Received: April 6, 2018
Peer-review started: April 7, 2018
First decision: May 16, 2018
Revised: July 23, 2018
Accepted: August 3, 2018
Article in press: August 4, 2018
Published online: September 10, 2018
Processing time: 155 Days and 13.7 Hours
Core Tip

Core tip: The objective of this study was to compare trends in liver transplant donor/recipient characteristics and outcomes using four period cohorts of adult, first-time whole-organ deceased donor recipients from 1990-2009 using historical data from the OPTN/UNOS database. The landscape of donors and recipients undergoing liver transplantation (LT) in the United States has changed. Donor age, body mass index, and the contribution of racial minorities have increased. Transplant recipients are older, more deconditioned and obese, and with changing causes of cirrhosis. Despite this, the long-term patient survival has improved over time. This paper provides an overview of the landscape of LT in the United States.