Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 24, 2016; 6(1): 54-68
Published online Mar 24, 2016. doi: 10.5500/wjt.v6.i1.54
Update on the treatment of focal segmental glomerulosclerosis in renal transplantation
Maria Messina, Ester Gallo, Alberto Mella, Fabiola Pagani, Luigi Biancone
Maria Messina, Ester Gallo, Alberto Mella, Fabiola Pagani, Luigi Biancone, Renal Transplantation Center “A. Vercellone”, Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital and University of Turin, 10126 Turin, Italy
Author contributions: Messina M, Gallo E, Mella A, Pagani F and Biancone L equally contributed to conception and design of the study, literature review, and analysis, drafting, critical revision and editing of the manuscript; all authors approved the final version.
Conflict-of-interest statement: None of the authors has any potential conflicts of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Luigi Biancone, MD, PhD, Renal Transplantation Center “A. Vercellone”, Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital and University of Turin, Corso Bramante 88, 10126 Turin, Italy. luigi.biancone@unito.it
Telephone: +39-011-6336797 Fax: +39-011-6334990
Received: November 15, 2015
Peer-review started: November 16, 2015
First decision: December 7, 2015
Revised: December 22, 2015
Accepted: January 21, 2016
Article in press: January 22, 2016
Published online: March 24, 2016
Processing time: 124 Days and 12.8 Hours
Core Tip

Core tip: Focal segmental glomerulosclerosis (FSGS) presents as a histological pattern of kidney damage with different, multifactorial, and often undefined pathogenesis. Primary FGSS represents one of the most severe glomerular diseases, with frequent progression to end-stage renal failure and a high rate of recurrence in renal allografts. FSGS recurrence also portends a negative outcome. Despite the proposal of multiple therapeutic approaches, none has emerged as the resolutive option. This review provides an update on the currently available therapeutic strategies for FSGS in renal transplantation, along with a critical overview of the related literature.