Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 24, 2015; 5(4): 261-266
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.261
Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.261
Immunomodulation with rabbit anti-thymocyte globulin in solid organ transplantation
Giovanbattista Ippoliti, Internal Medicine, Policlinico di Monza, 20900 Monza, Italy
Giovanbattista Ippoliti, Division of Cardiac Surgery, University of Pavia School of Medicine, Foundation “IRCCS San Matteo” Hospital, 27100 Pavia, Italy
Marco Lucioni, Marco Paulli, Anatomic Pathology, Foundation IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
Giuseppe Leonardi, Advanced Heart Failure Unit, AO Universitaria “Policlinico-V.Emanuele”, 95123 Catania, Italy
Author contributions: All authors contributed to the paper.
Conflict-of-interest statement: There are no relevant conflicts to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Giovanbattista Ippoliti, MD, Internal Medicine, Policlinico di Monza, Via Amati 111, 20900 Monza, Italy. g-ippoliti@libero.it
Telephone: +39-38-223510 Fax: +39-38-2049371
Received: June 26, 2015
Peer-review started: June 29, 2015
First decision: July 28, 2015
Revised: September 24, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 24, 2015
Processing time: 180 Days and 4.1 Hours
Peer-review started: June 29, 2015
First decision: July 28, 2015
Revised: September 24, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 24, 2015
Processing time: 180 Days and 4.1 Hours
Core Tip
Core tip: The effect of rabbit anti-thymocyte globulin on peripheral lymphocytes is believed to be cytolitic and hence to deplete, to opsonize and to apoptose T cells. Recent studies have shown that rabbit anti-thymocyte globulin also exerts an immunomodulatory effect on various components of immune response, such as adhesion molecules, dendritic cells and Foxp3+ Tregs.