Merhi B, Bayliss G, Gohh RY. Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney. World J Transplant 2015; 5(4): 251-260 [PMID: 26722652 DOI: 10.5500/wjt.v5.i4.251]
Corresponding Author of This Article
Reginald Y Gohh, MD, Department of Medicine, Division of Kidney Transplantation, Rhode Island Hospital, APC 10, 593 Eddy St., Providence, RI 02903, United States. rgohh@lifespan.org
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2015; 5(4): 251-260 Published online Dec 24, 2015. doi: 10.5500/wjt.v5.i4.251
Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney
Basma Merhi, George Bayliss, Reginald Y Gohh
Basma Merhi, George Bayliss, Department of Medicine, Division of Kidney Disease and Hypertension, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, United States
Reginald Y Gohh, Department of Medicine, Division of Kidney Transplantation, Rhode Island Hospital, Brown University School of Medicine, Providence, RI 02903, United States
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Reginald Y Gohh, MD, Department of Medicine, Division of Kidney Transplantation, Rhode Island Hospital, APC 10, 593 Eddy St., Providence, RI 02903, United States. rgohh@lifespan.org
Telephone: +1-401-4443284 Fax: +1-401-4443283
Received: August 12, 2015 Peer-review started: August 13, 2015 First decision: September 17, 2015 Revised: October 31, 2015 Accepted: November 17, 2015 Article in press: November 25, 2015 Published online: December 24, 2015 Processing time: 133 Days and 0.8 Hours
Core Tip
Core tip: Through its urine output, the transplanted kidney can provide a window into the cellular and molecular events occurring within the graft, and potentially offers a noninvasive means of assessing kidney allograft status. An assay consisting of biomarkers of allograft injury using only urine samples from transplant recipients could provide many advantages over the current strategy of relying on changes in the serum creatinine and kidney biopsies. A rising creatinine is a nonspecific marker of graft dysfunction and a relative late marker of intragraft pathology, whereas kidney biopsies are inherently invasive. The role of non-invasive monitoring through plasma or urine biomarkers has been a topic of interest to the transplant community for many years and has been the subject of numerous publications. Our objective is to critically review the current literature to better delineate the role of these urinary biomarkers in predicting the risk of acute allograft rejection in kidney transplant recipients.
