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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 24, 2014; 4(4): 222-228
Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.222
Published online Dec 24, 2014. doi: 10.5500/wjt.v4.i4.222
Challenges in pediatric renal transplantation
Licia Peruzzi, Alessandro Amore, Rosanna Coppo, University-Hospital Health Agency Città della Salute e della Scienza di Torino, Nephrology, Dialysis and Transplantation Unit, Regina Margherita University Children’s Hospital, 10126 Turin, Italy
Author contributions: Peruzzi L, Amore A and Coppo R equally reviewed the references, discussed the topic and wrote the paper.
Correspondence to: Licia Peruzzi, MD, PhD, University-Hospital Health Agency Città della Salute e della Scienza di Torino, Nephrology, Dialysis and Transplantation Unit, Regina Margherita University Children’s Hospital, Piazza Polonia 94, 10126 Turin, Italy. licia.peruzzi@unito.it
Telephone: +39-1-13131761 Fax: +39-1-16635543
Received: September 4, 2014
Revised: November 20, 2014
Accepted: December 3, 2014
Published online: December 24, 2014
Processing time: 116 Days and 16 Hours
Revised: November 20, 2014
Accepted: December 3, 2014
Published online: December 24, 2014
Processing time: 116 Days and 16 Hours
Core Tip
Core tip: Several novelties in the immunosuppressive treatment regimens in kidney transplantation in children are becoming available, with the aim of reducing the long terms side effects, particularly growth retardation, infections and malignancies, as well as improving the long term survival of the graft through a better treatment of chronic rejection. Moreover new induction drugs and specific protocols addressed to sensitized subjects may widen the possibility to receive a graft even for highly immunized children. These innovative aspects of therapy in kidney transplantation in children are reviewed.