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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 24, 2014; 4(3): 196-205
Published online Sep 24, 2014. doi: 10.5500/wjt.v4.i3.196
Published online Sep 24, 2014. doi: 10.5500/wjt.v4.i3.196
Intra-articular transplantation of porcine adipose-derived stem cells for the treatment of canine osteoarthritis: A pilot study
Shen-Yang Tsai, Lih-Seng Yeh, Institute of Veterinary Clinical Sciences, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
Yun-Ching Huang, Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi 60003, Taiwan
Ling-Ling Chueh, Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan
Ching-Shwun Lin, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-0738, United States
Author contributions: All authors contributed to this work.
Supported by The National Taiwan University
Correspondence to: Dr. Ching-Shwun Lin, Department of Urology, School of Medicine, University of California, 533 Parnassus Ave, San Francisco, CA 94143-0738, United States. clin@urology.ucsf.edu
Telephone: +1-415-4763800 Fax: +1-415-4763803
Received: December 21, 2013
Revised: March 16, 2014
Accepted: June 27, 2014
Published online: September 24, 2014
Processing time: 307 Days and 11 Hours
Revised: March 16, 2014
Accepted: June 27, 2014
Published online: September 24, 2014
Processing time: 307 Days and 11 Hours
Core Tip
Core tip: Intra-articular injection of autologous adipose-derived stem cells (ADSCs) has been shown to be effective in treating osteoarthritis in dogs. However, most veterinary clinics lack the equipment and expertise for ADSC isolation. The present study showed that intra-articular injection of porcine ADSCs into the diseased stifle joint of three dogs improved their mobility and activity and lessened their pain. The injection of porcine ADSCs elicited no signs of inflammation or immunological reaction. Thus, porcine ADSCs can substitute for autologous canine ADSCs, and such a treatment strategy can drastically reduce treatment cost.