Review
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World J Transplant. Jun 24, 2014; 4(2): 43-56
Published online Jun 24, 2014. doi: 10.5500/wjt.v4.i2.43
Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections
Christopher S Kovacs Jr, Christine E Koval, David van Duin, Amanda Guedes de Morais, Blanca E Gonzalez, Robin K Avery, Steven D Mawhorter, Kyle D Brizendine, Eric D Cober, Cyndee Miranda, Rabin K Shrestha, Lucileia Teixeira, Sherif B Mossad
Christopher S Kovacs Jr, Christine E Koval, Steven D Mawhorter, Kyle D Brizendine, Eric D Cober, Cyndee Miranda, Rabin K Shrestha, Lucileia Teixeira, Sherif B Mossad, Department of Infectious Diseases, Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, United States
David van Duin, Division of Infectious Diseases, Immunocompromised Host Infectious Disease Program, University of North Carolina, Chapel Hill, NC 27599, United States
Amanda Guedes de Morais, Infectious Disease and Internal Medicine, Augusta Health, Fishersville, VA 22939, United States
Blanca E Gonzalez, Department of Pediatric Infectious Diseases, Cleveland Clinic Children’s, Cleveland, OH 44195, United States
Robin K Avery, Division of Infectious Disease (Transplant/Oncology), Johns Hopkins, Baltimore, MD 21205, United States
Author contributions: Avery RK created the idea of an institutional approach for donor suitability; Koval CE, van Duin D, Mawhorter SD, Brizendine KD, Guedes de Morais A, Gonzalez BE, Cober ED, Miranda C, Shrestha RK, Teixeira L and Mossad S wrote material from which sections were synthesized and reviewed and approved the final draft; Kovacs Jr CS and Mossad SB coordinated and synthesized data, wrote, and compiled the final submitted draft.
Correspondence to: Sherif B Mossad, MD, Department of Infectious Diseases, Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Mailstop G-21, room 131, Cleveland, OH 44195, United States. mossads@ccf.org
Telephone: +1-216-4452572 Fax: +1-216-4459446
Received: December 20, 2013
Revised: March 21, 2014
Accepted: May 14, 2014
Published online: June 24, 2014
Core Tip

Core tip: The literature surrounding preventing donor-transmitted infections in solid organ transplant recipients has increased greatly in the last decade. Increased emphasis has been placed on improved diagnostics for screening of deceased donors. Importance has been placed on using donors who were previously thought to be high risk for transmitting infections to recipients and mitigating the risk to such recipients in an effort to increase the donor pool. Initiating the discussion around using human immunodeficiency virus (HIV) infected donors for HIV infected recipients has important implications for addressing the problem of allograft shortages.