Pahari H, Tripathi S, Nundy S. Frailty as a determinant of liver transplant outcomes: A call for integrative strategies. World J Transplant 2025; 15(3): 104500 [DOI: 10.5500/wjt.v15.i3.104500]
Corresponding Author of This Article
Hirak Pahari, MD, Department of Liver Transplant and Hepatobiliary Surgery, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi 110060, India. hirak.pahari@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Sep 18, 2025; 15(3): 104500 Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.104500
Frailty as a determinant of liver transplant outcomes: A call for integrative strategies
Hirak Pahari, Shikhar Tripathi, Samiran Nundy
Hirak Pahari, Department of Liver Transplant and Hepatobiliary Surgery, Sir Ganga Ram Hospital, New Delhi 110060, India
Shikhar Tripathi, Samiran Nundy, Department of Surgical Gastroenterology and Liver Transplant, Sir Ganga Ram Hospital, New Delhi 110060, India
Author contributions: Pahari H designed the overall concept and outline of the manuscript; Tripathi S contributed to the discussion and design of the manuscript; Pahari H, Tripathi S and Nundy S contributed to the writing and editing of the manuscript and review of literature.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hirak Pahari, MD, Department of Liver Transplant and Hepatobiliary Surgery, Sir Ganga Ram Hospital, Old Rajinder Nagar, New Delhi 110060, India. hirak.pahari@gmail.com
Received: December 23, 2024 Revised: March 9, 2025 Accepted: March 20, 2025 Published online: September 18, 2025 Processing time: 116 Days and 23.4 Hours
Core Tip
Core Tip: Frailty has emerged as a pivotal determinant of post-liver transplant (LT) outcomes, yet its integration into clinical practice remains inconsistent. Recent findings suggest that frail recipients experience significantly higher mortality within the first 12 months following transplantation—a period when traditional monitoring often wanes. Frailty, as a dynamic and modifiable condition, represents an opportunity for targeted intervention. Prehabilitation programs focusing on nutritional optimization, physical rehabilitation, and psychosocial support could enhance resilience in transplant candidates, reducing their risk profile and improving post-transplant outcomes. By addressing frailty comprehensively, we can move toward more personalized, effective strategies that improve survival and quality of life for LT recipients.
