Abbas K, Mubarak M, Musharraf W, Hafeez AR, Aziz T, Zafar MN. Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival. World J Transplant 2025; 15(3): 104308 [DOI: 10.5500/wjt.v15.i3.104308]
Corresponding Author of This Article
Khawar Abbas, Professor, Department of Transplant Immunology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sind, Pakistan. drkhawar_imuno@yahoo.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Sep 18, 2025; 15(3): 104308 Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.104308
Impact of low-level pretransplant donor-specific antibodies detected by the Luminex platform on acute rejection and long-term graft survival
Khawar Abbas, Muhammed Mubarak, Wajiha Musharraf, Abdul Rauf Hafeez, Tahir Aziz, Mirza Naqi Zafar
Khawar Abbas, Wajiha Musharraf, Department of Transplant Immunology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sind, Pakistan
Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Abdul Rauf Hafeez, Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Tahir Aziz, Department of Transplantation, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Mirza Naqi Zafar, Department of Pathology, Sindh Institute of Urology and Transplantation, Karachi 74200, Sindh, Pakistan
Co-corresponding authors: Khawar Abbas and Muhammed Mubarak.
Author contributions: Abbas K and Mubarak M contributed equally to the conception and study design; Abbas K, Mubarak M, Musharaf W, and Hafeez AF performed relevant research and participated in the primary and final drafting; Mubarak M, Aziz T, and Zafar MN critically reviewed and approved the final manuscript.
Institutional review board statement: The present study was approved by the Institutional Review Board of SIUT (SIUT-ERC-2020/A-417), and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.
Informed consent statement: All patients provided written informed consent.
Conflict-of-interest statement: All authors declared that they have no conflicts of interest related to this work.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khawar Abbas, Professor, Department of Transplant Immunology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sind, Pakistan. drkhawar_imuno@yahoo.com
Received: December 18, 2024 Revised: March 2, 2025 Accepted: March 10, 2025 Published online: September 18, 2025 Processing time: 121 Days and 22.6 Hours
Core Tip
Core Tip: Pretransplant low-level donor-specific antibodies (DSAs) detected by the Luminex platform are associated with favorable graft outcomes after 1 year and 10 years in kidney transplant recipients. This study highlighted the appropriate immunosuppressive induction and maintenance protocols. These patients experienced low rates of acute rejection and sustained satisfactory long-term graft function and survival. The majority of patients who experienced acute rejection showed a resolution of DSAs, underscoring the dynamic nature of antibodies. These findings support the clinical relevance of Luminex-detected low-level DSAs and reinforce the efficacy of contemporary immunosuppressive strategies in optimizing graft survival in this subset of transplant recipients.
