Disparities in liver transplantation for metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma

doi:10.5500/wjt.v15.i3.101997

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World Journal of Transplantation

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2220-3230

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World J Transplant. Sep 18, 2025; 15(3): 101997
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.101997

Disparities in liver transplantation for metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma

David W Victor, Sudha Kodali, Mazen Noureddin, Elizabeth W Brombosz, Analisa Lopez, Tamneet Basra, Edward A Graviss, Duc T Nguyen, Ashish Saharia, Ashton A Connor, Maen Abdelrahim, Yee Lee Cheah, Caroline J Simon, Mark J Hobeika, Constance M Mobley, R Mark Ghobrial

David W Victor, Sudha Kodali, Tamneet Basra, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, United States

Mazen Noureddin, Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, United States

Mazen Noureddin, Houston Research Institute, Houston, TX 77079, United States

Elizabeth W Brombosz, Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, United States

Analisa Lopez, JC Walter Jr Transplant Center, Houston Methodist Hospital, Houston, TX 77030, United States

Edward A Graviss, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, Texas 77030, United States

Duc T Nguyen, Department of Pediatrics, Baylor College of Medicine, Houston, 77030, United States

Ashish Saharia, Ashton A Connor, Yee Lee Cheah, Caroline J Simon, Mark J Hobeika, Constance M Mobley, JC Walter Jr Transplant Center, Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, United States

Maen Abdelrahim, Neal Cancer Center, Houston Methodist Hospital, Houston, TX 77030, United States

R Mark Ghobrial, J C Walter Jr Transplant Center, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, United States

Author contributions: Victor DW and Brombosz EW were responsible for preparation of the manuscript; Victor DW, Brombosz EW, and Ghobrial RM were responsible for conception or design of the work; Victor DW, Graviss EA, and Nguyen DT were responsible for acquisition and analysis of data; Victor DW, Kodali S, Noureddin M, Brombosz EW, Lopez A, Basra T, Graviss EA, Nguyen DT, Saharia A, Connor AA, Abdelrahim M, Cheah YL, Simon CJ, Hobeika MJ, Mobley CM, and Ghobrial RM were responsible for interpretation of data and review of the manuscript; all of the authors read and approved the final version of the manuscript to be published.

Institutional review board statement: This work was conducted under Houston Methodist Institutional Review Board protocol Pro00000587.

Informed consent statement: A publicly available dataset with deidentified data was used for this work; work was conducted under a waiver of consent from the Houston Methodist Institutional Review Board.

Conflict-of-interest statement: The authors have no conflicts to declare in relation to this work.

STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.

Data sharing statement: The data are publicly available from the US Scientific Registry of Transplant Recipients.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: David W Victor, MD, Director, Sherrie and Alan Conover Center for Liver Disease and Transplantation, Department of Medicine, Houston Methodist Hospital, 6550 Fannin Street, Houston, TX 77030, United States. dwvictor@houstonmethodist.org

Received: October 4, 2024
Revised: February 12, 2025
Accepted: February 21, 2025
Published online: September 18, 2025
Processing time: 195 Days and 20.2 Hours

Core Tip

Core Tip: Ethnicity, sex, and geographic region affect access to liver transplantation for hepatocellular carcinoma in the background of metabolic dysfunction-associated steatohepatitis, highlighting the need for strategies to address these discrepancies.