Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2025; 15(3): 101245
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.101245
Abnormal invasive hemodynamics in heart transplant recipients: A single-center, retrospective study
Navin Rajagopalan, Donna R Dennis, Julia Akhtarekhavari, Kenneth Campbell
Navin Rajagopalan, Donna R Dennis, Julia Akhtarekhavari, Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, United States
Kenneth Campbell, Department of Physiology, Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, United States
Author contributions: Rajagopalan N was responsible for study design and data analysis and primary role in writing the manuscript; Dennis DR and Akhtarekhavari J were responsible for study design and assisted with data acquisition; Campbell K was responsible for study design and statistical analysis; all authors contributed to the writing and editing of the manuscript, read and approved the final version of the manuscript to be published.
Institutional review board statement: Our retrospective analysis has been approved by the University of Kentucky’s Institutional Review Board. The title of the protocol that encompasses our research is titled: “Cardiovascular Outcomes Research and Education”. The Institutional Review Board at our institution governs the proper ethical conduct of research and all researchers agree to accept responsibility for the scientific and ethical conduct of the study.
Informed consent statement: Participants were not required to provide informed consent for this retrospective study. Data was de-identified and collected retrospectively for this cohort study.
Conflict-of-interest statement: Navin Rajagopalan has served as a consultant for Abbott Laboratories. The other authors have no conflicts of interest to report.
Data sharing statement: De-identified data can be requested and considered by the authors on a case-by-case basis.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Navin Rajagopalan, MD, Professor, Department of Internal Medicine, University of Kentucky, 900 South Limestone Street, Lexington, KY 40536, United States. navin_rajagopalan@yahoo.com
Received: September 8, 2024
Revised: February 16, 2025
Accepted: February 21, 2025
Published online: September 18, 2025
Processing time: 221 Days and 14.7 Hours
Core Tip

Core Tip: Our research demonstrates that abnormal invasive hemodynamics are commonly observed in heart transplant recipients at 1-year and 3-year post-transplantation. Obesity as reflected by body mass index was strongly associated with elevated right atrial, mean pulmonary artery, and pulmonary capillary wedge pressure in transplant recipients. Further research is needed to determine if the development of abnormal hemodynamics predicts transplant mortality and if behavioral modifications and pharmacologic therapy can reverse observed hemodynamic abnormalities.