Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2025; 15(3): 101046
Published online Sep 18, 2025. doi: 10.5500/wjt.v15.i3.101046
Incidence, screening, and management of de novo malignancies in liver transplant patients: A review
Anmol Singh, Carol Singh, Armaan Dhaliwal, Navdeep Singh, Vikash Kumar, Aalam Sohal, Jonathan Schneider
Anmol Singh, Department of Medicine, Tristar Centennial Medical Center, Nashville, TN 37203, United States
Carol Singh, Department of Medicine, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Armaan Dhaliwal, Division of Hematology and Oncology, Lehigh Valley Health Network, Allentown, PA 18103, United States
Navdeep Singh, Department of Medicine, Government Medical College, Amritsar 143001, Punjab, India
Vikash Kumar, Aalam Sohal, Division of Gastroenterology, Creighton University School of Medicine, Phoenix, AZ 85012, United States
Jonathan Schneider, Division of Gastroenterology, Tristar Centennial Medical Center, Nashville, TN 37203, United States
Author contributions: Singh A and Sohal A conceptualized and designed the study; Singh A, Singh C, Dhaliwal A and Singh N conducted the literature review, interpreted data, created artwork, and drafted the original manuscript; Kumar V, Singh A, Sohal A and Schneider J supervised the study and made critical revisions.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Aalam Sohal, Academic Fellow, Division of Gastroenterology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, United States. aalamsohal@gmail.com
Received: September 3, 2024
Revised: January 29, 2025
Accepted: February 27, 2025
Published online: September 18, 2025
Processing time: 227 Days and 8 Hours
Core Tip

Core Tip: Liver transplantation (LT) is crucial for treating severe liver conditions, but it increases the risk of new cancers, especially non-melanoma skin cancers like squamous cell carcinoma. LT recipients also have a higher chance of developing solid organ cancers and lymphoproliferative disorders compared to the general population. Key risk factors include chronic immunosuppression, alcohol or tobacco use, and viral infections. Effective management involves regular cancer screenings, early detection, and adjusting immunosuppressive treatments, particularly for Kaposi's sarcoma and post-transplant lymphoproliferative disorders.