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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2025; 15(2): 103247
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.103247
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.103247
Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for CYP3A5-polymorphism in kidney-transplant recipients
Pham-Thai Dung, Center of Critical Care Medicine, Emergency and Clinical Toxicology, Military Hospital, Hanoï 100000, Viet Nam
Hoang-Xuan Su, Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, Hanoï 100000, Viet Nam
Nguyen-Chi Tue, Department of Post-Transplant Intensive Care and Treatment, Center of Organ Transplantation - Military Hospital, Hanoï 100000, Viet Nam
Nguyen-Huu Ben, Nguyen-Minh Phuong, Department of Occupational Medicine, Vietnam Military Medical University, Hanoï 100000, Viet Nam
Tuan-Ngoc Tran, Department of Military Medical Command and Organization, Vietnam Military Medical University, Hanoï 100000, Viet Nam
Phan-Ba Nghia, Diem-Thi Van, Nguyen Thi-Thuy Dung, Hoang-Trung Vinh, Lionel Rostaing, Pham-Quoc Toan, Department of Nephrology and Dialysis, Military Hospital, Hanoï 100000, Viet Nam
Lionel Rostaing, Department of Nephrology, Hemodialysis, Apheresis, and Kidney Transplan
Author contributions: Dung PT contributed to the formal analysis of the manuscript and wrote the original manuscript preparation; Su HX contributed to the resources of the manuscript; Toan PQ conceptualized the manuscript; Ben NH applied the software; Phuong NM validated the manuscript; Rostaing L contributed to the supervision of the manuscript; Toan PQ performed the project management and the acquisition of funds; Dung PT and Su HX for methodology; Dung PT, Toan PQ, and Su HX for survey; Tue NC, Nghia PB, Van DT, Dung NTT, Tue NC, Nghia PB, Van DT, and Dung NTT for data organization of the manuscript; Toan PQ, and Rostaing L wrote, reviewed, and edited the manuscript; Vinh HT and Tran TN visualized; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the Vietnam National Foundation for Science and Technology Development, No. NAFOSTED 04/2020/TN.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam, approval No. November 25th, 2022).
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement:
Data are available upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lionel Rostaing, MD, PhD, Professor, Department of Nephrology and Dialysis, Military Hospital, Phung Hung Street, Hanoï 100000, Viet Nam.
Received: November 15, 2024
Revised: December 17, 2024
Accepted: January 2, 2025
Published online: June 18, 2025
Processing time: 98 Days and 18.6 Hours
Revised: December 17, 2024
Accepted: January 2, 2025
Published online: June 18, 2025
Processing time: 98 Days and 18.6 Hours
Core Tip
Core Tip: We included in this single-center retrospective study 86 de novo kidney transplant recipients with tacrolimus (TAC)-based immunosuppression. This study aims to evaluate the predictive value of the TAC concentration-to-dose (C0/D) ratio for identifying CYP3A5 polymorphisms within the first week after kidney transplantation. We found that the TAC C0/D ratio provides a reliable predictive value for CYP3A5 polymorphisms, which can be used to individualize TAC dosing in kidney transplant recipients in low-income countries.