Cardiac transplantation: A review of current status and emerging innovations

doi:10.5500/wjt.v15.i2.100460

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Jun 18, 2025 (publication date) through Feb 21, 2025

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Jun 18, 2025; 15(2): 100460
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.100460

Cardiac transplantation: A review of current status and emerging innovations

Umashri Sundararaju, Srinivas Rachoori, Abdulkader Mohammad, Hamrish Kumar Rajakumar

Umashri Sundararaju, Srinivas Rachoori, Hamrish Kumar Rajakumar, Department of General Surgery, Government Medical College, Omandurar Government Estate, Chennai 600002, Tamil Nādu, India

Abdulkader Mohammad, Department of Medicine, University of Novi Sad, Novi Sad 21000, Serbia

Author contributions: Sundararaju U contributed to the conceptualization, created the visualizations, and provided resources; Rachoori S contributed to the conceptualization, investigation, drafting of the manuscript, and visualizations; Mohammed A was involved in the conceptualization, methodology, investigation; Rajakumar HK conceptualized and designed the study, developed the methodology, supervised the project, and provided necessary resources; Sundararaju U and Rajakumar HK conducted the investigation, managed administration; Sundararaju U, Mohammed A, and Rajakumar HK drafted the original manuscript; and all authors prepared the draft and approved the submitted version.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hamrish Kumar Rajakumar, Department of General Surgery, Government Medical College, Omandurar Government Estate, No. 169 Wallahjah Road, Police Quarters, Chennai 600002, Tamil Nādu, India. hamrishkumar2003@gmail.com

Received: August 19, 2024
Revised: December 20, 2024
Accepted: December 27, 2024
Published online: June 18, 2025
Processing time: 188 Days and 13.4 Hours

Core Tip

Core Tip: Cardiac transplantation remains a vital treatment for end-stage heart disease. Recent advancements in artificial hearts, mechanical circulatory support devices, and xenotransplantation have tackled both technological and ethical challenges, providing new solutions for managing severe heart failure and addressing organ shortages. Innovations in regenerative medicine and stem cell therapy are offering fresh approaches to cardiac repair, while remote monitoring technologies are improving post-operative care and outcomes. Ongoing research is transforming heart transplantation, aiming to enhance patient prognosis and quality of life while addressing existing limitations, and shaping the future of this crucial field.