Observational Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2025; 15(2): 100427
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.100427
Liver transplant practices in the era of normothermic machine perfusion in the United States
Kenji Okumura, Abhay Dhand, Bima J Hasjim, Ryosuke Misawa, Hiroshi Sogawa, Gregory Veillette, Seigo Nishida
Kenji Okumura, Abhay Dhand, Ryosuke Misawa, Hiroshi Sogawa, Gregory Veillette, Seigo Nishida, Department of Surgery, Westchester Medical Center, Valhalla, NY 10595, United States
Bima J Hasjim, Department of Surgery, University of California, Irvine Medical Center, Orange, CA 92697, United States
Author contributions: Okumura K, Misawa R, Nishida S contributed to concept design; Okumura K, Dhand A, Misawa R, Nishida S contributed to data analysis interpretation; Okumura K, Dhand A, Nishida S contributed to drafting article; Okumura K, Dhand A, Misawa R, Sogawa H, Veillette G contributed to critical revision of article.
Institutional review board statement: This study was approved by our local Institutional Review Board.
Informed consent statement: Informed consent is waived.
Conflict-of-interest statement: All the authors of this manuscript declare no funding or conflicts of interest to disclose.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement- checklist of items.
Data sharing statement: The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kenji Okumura, MD, Assistant Professor, Department of Surgery, Westchester Medical Center, 100 Woods Rd, Valhalla, NY 10595, United States. kenji.okumura@wmchealth.org
Received: August 18, 2024
Revised: December 5, 2024
Accepted: December 27, 2024
Published online: June 18, 2025
Processing time: 189 Days and 9 Hours
Core Tip

Core Tip: The utilization of normothermic liver machine perfusion is associated with lower discard rates, increased utilization of donation after circulatory death liver allografts and an ability to expand the distance between recipient and donor hospitals, prolong preservation time, and higher occurrence of daytime liver transplant without any negative impact on the survival outcomes.