Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2025; 15(2): 100065
Published online Jun 18, 2025. doi: 10.5500/wjt.v15.i2.100065
Characteristics and outcomes of Bahraini pediatric patients sent abroad for bone marrow transplantation: A ten-year retrospective cohort study
Hasan M Isa, Shahd T Bucheeri, Jarrah Y Aldoseri, Ayah A Redha, Abdulla F Mubarak, Shaikha A Altamimi, Ameera A AlOraibi, Mohamed I Alshaikh
Hasan M Isa, Department of Pediatrics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 26671, Bahrain
Hasan M Isa, Ameera A AlOraibi, Mohamed I Alshaikh, Department of Pediatrics, Salmaniya Medical Complex, Manama 26671, Bahrain
Shahd T Bucheeri, Jarrah Y Aldoseri, Ayah A Redha, Abdulla F Mubarak, School of Medicine, Royal College of Surgeons in Ireland-Medical University of Bahrain, Busaiteen 15503, Bahrain
Shaikha A Altamimi, The Overseas Office, Supreme Committee for Treatment Abroad, Ministry of Health, Manama 26671, Bahrain
Author contributions: All authors made substantial contributions to this paper. Isa HM was the main contributor in study design, data analysis, and overseeing all phases of the project; Bucheeri ST and Aldoseri JY were responsible for literature review, data collection, data analysis, drafting, and manuscript revision; Redha AA and Mubarak AF were responsible for literature review, data collection, and manuscript revision; Altamimi SA, AlOraibi AA, and Alshaikh MI were responsible for project supervision. All the authors have read and approved the final manuscript.
Institutional review board statement: The study was conducted per the principles of the Helsinki Declaration of 1975 (revised 2013), and it was ethically approved by the Research and Research Ethics Committee, Salmaniya Medical Complex, Government hospitals, Kingdom of Bahrain (IRB number: 110311023, November 6, 2023).
Informed consent statement: Consent was not needed as the study was retrospective without exposure to the patients’ data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: Data are available upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hasan M Isa, MBChB, Associate Professor, Consultant Physician-Scientist, Department of Pediatrics, Salmaniya Medical Complex, No. 2904, Al Salmaniya Area, Manama 26671, Bahrain. halfaraj@hotmail.com
Received: August 11, 2024
Revised: December 20, 2024
Accepted: January 7, 2025
Published online: June 18, 2025
Processing time: 193 Days and 16.7 Hours
Core Tip

Core Tip: The clinical characteristics and outcomes of Bahraini children who underwent overseas bone marrow transplantation (BMT) have not been previously studied. Here, we found a male predominance among BMT recipients. The most common indications were acute myeloid leukemia (AML) and lymphoblastic leukemia. Most patients received allogeneic grafts. Although the overall survival rate was 77.4%, the incidence of infectious complications was high. Survival rates varied according to BMT indications and centers. Non-AML patients and those who underwent BMT in Middle Eastern countries had better survival outcomes. BMT remains a life-saving procedure for patients with oncological and hematological conditions.