Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 18, 2025; 15(1): 96025
Published online Mar 18, 2025. doi: 10.5500/wjt.v15.i1.96025
Future of non-invasive graft evaluation: A systematic review of proteomics in kidney transplantation
Eleni Avramidou, Konstantina Psatha, Kallisti St John, Georgios Tsoulfas, Michalis Aivaliotis
Eleni Avramidou, Georgios Tsoulfas, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University of Thessaloniki, School of Medicine, Thessaloniki 54642, Greece
Konstantina Psatha, Laboratory of Medical Biology- Genetics, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Konstantina Psatha, Kallisti St John, Michalis Aivaliotis, Functional Proteomics and Systems Biology (FunPATh), Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Thessaloniki GR-57001, Greece
Kallisti St John, Michalis Aivaliotis, Laboratory of Biological Chemistry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Co-corresponding authors: Eleni Avramidou and Michalis Aivaliotis.
Author contributions: Avramidou E and Aivaliotis M conceptualized and designed the research; Avramidou E and St John K performed the research through the databases; Avramidou E and St John K analysed the data; Avramidou E, St John K and Psatha K wrote the paper; Tsoulfas G and Aivaliotis M critically reviewed the paper. All the authors have read and approved the final manuscript. Avramidou E proposed the research idea and searched the databases. Aivaliotis M provided the analysis sources. The collaboration between Avramidou E and Aivaliotis M is crucial for the publication of this manuscript and other manuscripts still in preparation.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eleni Avramidou, Department of Transplantation Surgery, Center for Research and Innovation in Solid Organ Transplantation, Aristotle University of Thessaloniki, School of Medicine, 49 Konstantinoupoleos Street, Thessaloniki 54642, Greece. avramidoue@auth.gr
Received: April 24, 2024
Revised: September 19, 2024
Accepted: October 21, 2024
Published online: March 18, 2025
Processing time: 216 Days and 13.4 Hours
Core Tip

Core Tip: In recent years, the role of diagnostic biomarkers in kidney transplantation has been emerged, particularly with proteomics being considered a powerful investigative tool. In this review, we critically analyze the spectrum of proteins exhibiting diagnostic accuracy in early, non-invasive evaluation of kidney grafts as well as the potent biological correlations between the variation of proteins detected in recipients experiencing some type of graft dysfunction or complication.