Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2024; 14(4): 98797
Published online Dec 18, 2024. doi: 10.5500/wjt.v14.i4.98797
Prostaglandin E1 administration post liver transplantation and renal outcomes: A retrospective single center experience
Vinay Jahagirdar, Mohamed Ahmed, Ifrah Fatima, Hassam Ali, Laura Alba, John H Helzberg, Lee S Cummings, Matthew Wilkinson, Jameson Forster, Alisa Likhitsup
Vinay Jahagirdar, Mohamed Ahmed, Ifrah Fatima, Department of Internal Medicine, Saint Luke’s Health System of Kansas City and the University of Missouri-Kansas City, Kansas City, MO 64111, United States
Hassam Ali, Department of Gastroenterology and Hepatology, East Carolina University Brody School of Medicine, Greenville, NC 27834, United States
Laura Alba, John H Helzberg, Division of Internal Medicine, Department of Gastroenterology and Hepatology, Saint Luke’s Health System of Kansas City and University of Missouri-Kansas City, Kansas City, MO 64111, United States
Lee S Cummings, Matthew Wilkinson, Jameson Forster, Department of Surgery, University of Missouri-Kansas City and Transplant Surgery, Saint Luke’s Hospital of Kansas City, Kansas City, MO 64111, United States
Alisa Likhitsup, Department of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, United States
Author contributions: Jahagirdar V, Ahmed M, and Fatima I were responsible for drafting the manuscript, performing the literature review, data collection, and validation; Alba L, Helzberg J, Cummings L, Wilkinson M, and Forster J contributed to the critical review and editing of the manuscript; Ali H contributed to project administration; Likhitsup A was responsible for study conception, analysis, critical reviewing, and supervision; all authors reviewed the results and approved the final version of the manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of the institute. Research was conducted in accordance with the ethical standards of the institutional and/or national research committee.
Informed consent statement: Given the retrospective nature of this study, the need for informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest related to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hassam Ali, MD, Doctor, Department of Gastroenterology and Hepatology, East Carolina University Brody School of Medicine, 2100 Stantonsburg Road, Greenville, NC 27834, United States. alih20@ecu.edu
Received: July 6, 2024
Revised: August 21, 2024
Accepted: September 2, 2024
Published online: December 18, 2024
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Core Tip

Core Tip: This retrospective study examines the renal outcomes of prostaglandin E1 (PGE1) administration following liver transplantation (LT). Despite the PGE1 group experiencing initial acute renal injury and higher postoperative complications, their long-term renal function (up to 12 months) was comparable to those not receiving PGE1. The findings suggest that PGE1 may offer renoprotective benefits, warranting further prospective clinical trials to evaluate its potential in mitigating renal dysfunction post-LT.