Impact of bisphosphonate treatment on bone mineral density after kidney transplant

doi:10.5500/wjt.v14.i3.92335

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Sep 18, 2024; 14(3): 92335
Published online Sep 18, 2024. doi: 10.5500/wjt.v14.i3.92335

Impact of bisphosphonate treatment on bone mineral density after kidney transplant

Georgia Andriana Georgopoulou, Marios Papasotiriou, Theodoros Ntrinias, Eirini Savvidaki, Dimitrios S Goumenos, Evangelos Papachristou

Georgia Andriana Georgopoulou, Marios Papasotiriou, Theodoros Ntrinias, Eirini Savvidaki, Dimitrios S Goumenos, Evangelos Papachristou, Department of Nephrology and Kidney Transplantation, University Hospital of Patras, Patras 26504, Greece

Author contributions: Papachristou E, Goumenos DS and Papasotiriou M designed the overall concept and outlined the manuscript; Georgopoulou GA and Ntrinias T contributed to the discussion and design of the manuscript; Papasotiriou M and Georgopoulou GA contributed to the writing and editing of the manuscript and illustrations; Savvidaki E contributed to the literature review; and all authors have read and approved the final manuscript.

Institutional review board statement: This retrospective cohort study was approved by the hospital’s Ethics Committee and was performed in accordance with the 1975 Helsinki Declaration.

Informed consent statement: All study participants, or their legal authorized representative, provided informed written consent prior to study enrollment.

Conflict-of-interest statement: The authors declare no conflicts of interest.

Data sharing statement: The technical appendix, statistical code, and datasets are available from the corresponding author at mpapasotiriou@yahoo.com and mpapasotir@upatras.gr.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Marios Papasotiriou, MD, PhD, Assistant Professor, Department of Nephrology and Kidney Transplantation, University Hospital of Patras, Patras 26504, Greece. mpapasotiriou@yahoo.com

Received: January 22, 2024
Revised: March 4, 2024
Accepted: July 2, 2024
Published online: September 18, 2024
Processing time: 190 Days and 9 Hours

Core Tip

Core Tip: Mineral bone disease can occur in patients with chronic kidney disease and is highly prevalent among patients after kidney transplantation. In this study, antiresorptive treatment with bisphosphonates had a beneficial effect on bone mineral density (BMD) in kidney transplant recipients (KTRs) irrespective of baseline BMD values. KTRs who received no treatment showed a non-significant decrease in BMD.