Dilibe A, Subramanian L, Poyser TA, Oriaifo O, Brady R, Srikanth S, Adabale O, Bolaji OA, Ali H. Tacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation. World J Transplant 2024; 14(2): 91146 [PMID: 38947962 DOI: 10.5500/wjt.v14.i2.91146]
Corresponding Author of This Article
Hassam Ali, MD, Doctor, Division of Gastroenterology and Hepatology, East Carolina University/Brody School of Medicine, 2100 Statonsburg Road, Greenville, Greenville, NC 27858, United States. hassamali155@gmail.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Jun 18, 2024; 14(2): 91146 Published online Jun 18, 2024. doi: 10.5500/wjt.v14.i2.91146
Tacrolimus-induced posterior reversible encephalopathy syndrome following liver transplantation
Arthur Dilibe, Lakshmi Subramanian, Tracy-Ann Poyser, Osejie Oriaifo, Ryan Brady, Sashwath Srikanth, Olanrewaju Adabale, Olayiwola Akeem Bolaji, Hassam Ali
Arthur Dilibe, Lakshmi Subramanian, Osejie Oriaifo, Sashwath Srikanth, Olanrewaju Adabale, Department of Medicine, ECU Health Medical Center, Greenville, NC 27834, United States
Tracy-Ann Poyser, Department of Medicine, Unity Health-White County Medical Center, Searcy, AR 72143, United States
Ryan Brady, Department of Physical Medicine and Rehab, ECU Health Medical Center, Greenville, NC 27834, United States
Olayiwola Akeem Bolaji, Department of Medicine, University of Maryland Capital Region Health, Largo, MD 20774, United States
Hassam Ali, Division of Gastroenterology and Hepatology, East Carolina University/Brody School of Medicine, Greenville, NC 27858, United States
Author contributions: Ali H contributed to the discussion and design of the manuscript; Poyser TA and Brady R contributed to the writing, and editing the manuscript, illustrations, and review of literature; Adabale O and Oriaifo O contributed to data collection and analysis; Subramanian L and Srikanth S contributed to the writing, editing the manuscript, ethical considerations and statistical analysis; Bolaji O and Ali H contributed to fieldwork and preliminary data analysis.
Conflict-of-interest statement: No conflicts of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hassam Ali, MD, Doctor, Division of Gastroenterology and Hepatology, East Carolina University/Brody School of Medicine, 2100 Statonsburg Road, Greenville, Greenville, NC 27858, United States. hassamali155@gmail.com
Received: December 23, 2023 Revised: April 13, 2024 Accepted: April 25, 2024 Published online: June 18, 2024 Processing time: 174 Days and 7.7 Hours
Core Tip
Core Tip: Tacrolimus, a crucial immunosuppressant in liver transplantation, is associated with the rare but serious complication of posterior reversible encephalopathy syndrome (PRES). Although the incidence is relatively low (0.5%-5%) in solid organ transplant recipients, the presentation of PRES can vary significantly, including seizures and visual disturbances. This condition, primarily affecting the parietal and occipital lobes, underscores the need for diligent monitoring and early intervention in liver transplant patients undergoing Tacrolimus therapy. The case presented highlights the complexities in diagnosing and managing Tacrolimus-related PRES, emphasizing the critical balance between adequate immunosuppression and the risk of severe neurological adverse effects.
