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World J Transplant. Mar 18, 2024; 14(1): 89978
Published online Mar 18, 2024. doi: 10.5500/wjt.v14.i1.89978
Management strategies for common viral infections in pediatric renal transplant recipients
Randula Ranawaka, Kavinda Dayasiri, Erandima Sandamali, Manoji Gamage
Randula Ranawaka, Department of Paediatrics, Faculty of Medicine, University of Colombo and Lady Ridgeway Hospital for Children, Colombo 0094, Sri Lanka
Kavinda Dayasiri, Department of Paediatrics, Facullty of Medicine, University of Kelaniya, Ragama 0094, Sri Lanka
Erandima Sandamali, Department of Nursing, Faculty of Allied Health Sciences, University of Ruhuna, Galle 0094, Sri Lanka
Manoji Gamage, Division of Nutrition, Ministry of Health, Colombo 0094, Sri Lanka
Author contributions: Ranawaka R, Dayasiri K, Sandamali E, Gamage M performed literature survey; Ranawaka R, Dayasiri K, Sandamali E, Gamage M wrote the manuscript; Ranawaka R edited the final version of the manuscript; all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Randula Ranawaka, MBBS, MD, Chief Physician, Professor, Senior Researcher, Department of Paediatrics, Faculty of Medicine, University of Colombo and Lady Ridgeway Hospital for Children, Kynsey Road, Colombo 0094, Sri Lanka. randula@pdt.cmb.ac.lk
Received: November 20, 2023
Peer-review started: November 20, 2023
First decision: December 11, 2023
Revised: December 19, 2023
Accepted: January 4, 2024
Article in press: January 4, 2024
Published online: March 18, 2024
Processing time: 116 Days and 4.1 Hours
Core Tip

Core Tip: Pediatric renal transplant recipients are at high risk of acquiring virus-related complications due to immunological immaturity and the enhanced alloreactivity risk that led to maintenance of high immunosuppressive regimes. Prevention, early detection, and prompt treatment of such infections are important. Recent advances in technology and antiviral therapy have improved management strategies in screening, monitoring, adoption of preemptive therapy and precise treatment in the immunocompromised host, with significant impact on the outcome.