Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Mar 18, 2024; 14(1): 89822
Published online Mar 18, 2024. doi: 10.5500/wjt.v14.i1.89822
Pros and cons of live kidney donation in prediabetics: A critical review and way forward
Muhammad Abdul Mabood Khalil, Nihal Mohammed Sadagah, Jackson Tan, Furrukh Omair Syed, Vui Heng Chong, Salem H Al-Qurashi
Muhammad Abdul Mabood Khalil, Nihal Mohammed Sadagah, Furrukh Omair Syed, Salem H Al-Qurashi, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital Jeddah, Jeddah 23311, Saudi Arabia
Jackson Tan, Department of Nephrology, RIPAS Hospital Brunei Darussalam, Brunei Muara BA1710, Brunei Darussalam
Vui Heng Chong, Division of Gastroenterology and Hepatology, Department of Medicine, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan BA1710, Brunei Darussalam
Author contributions: Khalil MAM, Al-Qurashi SH, Sadagah NM conceived the idea of the study, and all authors critically reviewed the draft; Khalil MAM revised the manuscript and all authors approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad Abdul Mabood Khalil, FCPS, FRCP, MRCP, Doctor, Center of Renal Diseases and Transplantation, King Fahad Armed Forces Hospital Jeddah, Al Kurnaysh Br Rd, Al Andalus, Jeddah 23311, Saudi Arabia. doctorkhalil1975@hotmail.com
Received: November 13, 2023
Peer-review started: November 13, 2023
First decision: November 29, 2023
Revised: December 11, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: March 18, 2024
Core Tip

Core Tip: An increasing number of prediabetic kidney donors are encountered by transplant physicians. The decision to allow or to not allow these donors is always challenging. Prediabetics are prone to multiple complications in the future, including diabetes mellitus and chronic kidney disease. Variability in recommendations by various organizations and societies about kidney donation in prediabetics leads to even further confusion in decision making. This extensive review focuses on evidence from both the general population and kidney donors regarding kidney donation in prediabetics. This review will help clinicians to take well informed decisions and to identify a direction for further research and the need for a uniform position by international transplant societies like The Transplantation Society or International Society of Nephrology.