Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Dec 18, 2023; 13(6): 331-343
Published online Dec 18, 2023. doi: 10.5500/wjt.v13.i6.331
Predictors of graft function and survival in second kidney transplantation: A single center experience
Mahmoud Khalil, Rabea Ahmed Gadelkareem, Medhat Ahmed Abdallah, Mohamed Abdel-Basir Sayed, Fathy Gaber Elanany, Paolo Fornara, Nasreldin Mohammed
Mahmoud Khalil, Rabea Ahmed Gadelkareem, Medhat Ahmed Abdallah, Mohamed Abdel-Basir Sayed, Fathy Gaber Elanany, Nasreldin Mohammed, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Assiut 71515, Assiut, Egypt
Paolo Fornara, Department of Urology and Kidney Transplantation, Martin Luther University, Halle (Saale) 71515, Germany
Author contributions: Khalil M and Gadelkareem RA designed the research, collected the data, performed statistical analysis and wrote the paper; Abdallah MA, Mohammed N and Sayed MA contributed to data collection, literature review, writing and revision; and Elanany FG and Fornara P contributed to literature review, writing, revision and supervision of the work; All authors approved the paper.
Institutional review board statement: The authors confirm that all the experimental protocols of this study were approved by the Ethical Committee (Institutional Review Board; IRB) of the Faculty of Medicine, Assiut University, Egypt and Martin-Luther University, Germany (IRB approval number: 17200548/2015).
Informed consent statement: This article is a retrospective study. Hence, the patients were not required to give informed consent to the study, because the manipulated data were anonymous and were obtained after each patient, with his potential kidney donor(s), agreed to the plan of management.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
Data sharing statement: The data supporting this study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rabea Ahmed Gadelkareem, MD, Assistant Professor, Department of Urology, Assiut Urology and Nephrology Hospital, Faculty of Medicine, Assiut University, Elgamaa Street, Assiut 71515, Assiut, Egypt. dr.rabeagad@yahoo.com
Received: August 16, 2023
Peer-review started: August 16, 2023
First decision: September 14, 2023
Revised: October 19, 2023
Accepted: November 3, 2023
Article in press: November 3, 2023
Published online: December 18, 2023
Core Tip

Core Tip: Second kidney transplantation (SKT) is a viable option for patients with failed first kidney transplantation (FKT). Although the first primary nonfunction graft is a common contributor to SKT, it is also a potential outcome among a major proportion of those populations. Also, it is a significant risk factor for graft survival among those patients with functioning SKTs. Hence, the non-immediate recovery of the first graft function and delayed graft function in the second graft are significantly associated with unfavorable second graft survival rates. Inspite of this wide spectrum of risk factors, patient and graft survival rates in SKT seemed to be similar to those of FKT. SKT should be recommended for patients with failed FKT.