Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Sep 18, 2023; 13(5): 264-275
Published online Sep 18, 2023. doi: 10.5500/wjt.v13.i5.264
Invasive aspergillosis in liver transplant recipients, an infectious complication with low incidence but significant mortality
Azam Farahani, Fereshteh Ghiasvand, Setareh Davoudi, Zahra Ahmadinejad
Azam Farahani, Fereshteh Ghiasvand, Setareh Davoudi, Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 1478714466, Iran
Zahra Ahmadinejad, Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran 1478714466, Iran
Author contributions: Ahmadinejad Z designed the research study, translate the article into English and revised the manuscript according to the reviewer comments; Farahani A performed the research, analyzed the data and prepared the draft of manuscript in Persian language; Ghiasvand F and Davoudi S scientifically and grammatically edit the translated manuscript; All authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional research ethics committee, school of medicine, Tehran university of medical sciences (Approval No. IR.TUMS.MEDICINE.REC.1399.874).
Informed consent statement: Informed consent was waived by the EBR due to retrospective pattern of the study. However the questionnaires were anonymous.
Conflict-of-interest statement: There is no any conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zahra Ahmadinejad, MD, Full Professor, Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, KESHAVARZ Blvd, Dr Gharib Street, Tehran 1478714466, Iran. ahmadiz@tums.ac.ir
Received: June 28, 2023
Peer-review started: June 28, 2023
First decision: August 4, 2023
Revised: August 17, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: September 18, 2023
Processing time: 78 Days and 8.9 Hours
Core Tip

Core Tip: In our center, invasive aspergillosis had a low incidence but a high mortality rate among liver transplant recipients. Invasive pulmonary aspergillosis was the most prevalent form of infection. Nodules, pleural effusion, and halo signs were the most commonly observed findings on chest computed tomography scans. Antifungal prophylaxis was more prevalent in the case group than in the control group. At week 6 of antifungal treatment, more than 60% of patients experienced complete recovery or relative response to therapy.