Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation

doi:10.5500/wjt.v13.i5.254

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Transplant. Sep 18, 2023; 13(5): 254-263
Published online Sep 18, 2023. doi: 10.5500/wjt.v13.i5.254

Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation

Maria Clara Morais, Maria Eduarda Soares, Gabriela Costa, Laura Guerra, Nayana Vaz, Liana Codes, Paulo Lisboa Bittencourt

Maria Clara Morais, Gabriela Costa, Laura Guerra, Nayana Vaz, Liana Codes, Paulo Lisboa Bittencourt, School of Medicine, Bahiana School of Medicine and Public Health, Salvador 40290-000, Bahia, Brazil

Maria Eduarda Soares, School of Medicine, Federal University of Bahia, Salvador 40110-100, Bahia, Brazil

Nayana Vaz, Liana Codes, Paulo Lisboa Bittencourt, Unit of Gastroenterology and Hepatology, Portuguese Hospital, Salvador 40130-030, Bahia, Brazil

Author contributions: Morais MC, Codes L, and Bittencourt PL contributed to concept and design; Morais MC, Costa G, Guerra L, Vaz N, Codes L, and Bittencourt PL contributed to drafting of the manuscript; and all authors have read and approved the final version of the manuscript.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Paulo Lisboa Bittencourt, MD, PhD, Chief Doctor, Unit of Gastroenterology and Hepatology, Portuguese Hospital, 914 Av. Princesa Isabel, Barra, Salvador 40130-030, Bahia, Brazil. plbbr@uol.com.br

Received: June 28, 2023
Peer-review started: June 28, 2023
First decision: July 19, 2023
Revised: July 31, 2023
Accepted: August 11, 2023
Article in press: August 11, 2023
Published online: September 18, 2023
Processing time: 78 Days and 16.3 Hours

Core Tip

Core Tip: Tacrolimus is widely used after solid organ transplantation. High intra-patient variability of tacrolimus (Tac IPV) has been associated with poor graft and patient survival. This review summarizes current evidence regarding the impact of high Tac IPV in several outcomes after kidney, liver, heart, lung and pancreas transplantation.