Retrospective Cohort Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Feb 18, 2023; 13(2): 44-57
Published online Feb 18, 2023. doi: 10.5500/wjt.v13.i2.44
Analysis of the effects of donor and recipient hepatitis C infection on kidney transplant outcomes in the United States
Qing Yuan, Shanjuan Hong, Gregory Leya, Eve Roth, Georgios Tsoulfas, WW Williams, Joren C Madsen, Nahel Elias
Qing Yuan, Department of Urology, Chinese PLA General Hospital, Beijing 100853, China
Qing Yuan, Shanjuan Hong, Gregory Leya, Eve Roth, WW Williams, Joren C Madsen, Nahel Elias, Transplant Center and Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA 02114, United States
Georgios Tsoulfas, Department of Surgery, Aristototle University of Thessaloniki, Thessaloniki 541 24, Greece
WW Williams, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, United States
Joren C Madsen, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA 02114, United States
Nahel Elias, Division of Transplant Surgery, Massachusetts General Hospital, Boston, MA 02114, United States
Author contributions: Yuan Q and Elias N contributed to study conception and design; Acquisition of data: Elias N contributed to analysis and interpretation of data; Yuan Q, Hong S, Leya G, Roth E, Tsoulfas G, Williams WW and Elias N contributed to analysis and interpretation of data; Yuan Q, Hong S, Leya G, Roth E, Tsoulfas G, Williams WW and Elias N contributed to drafting of manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: The above referenced project does not meet the criteria for human subject research as defined by Mass General Brigham Human Research Office policies and Health and Human Services regulations set forth in 45 CFR 46. Based on the information you provided this activity is not human subjects research because it does not involve human subjects. The project does not require IRB approval.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The data sources for this study are publicly available from the OPTN web site: http://optn.transplant.hrsa.gov.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nahel Elias, MD, Assistant Professor, Surgeon, Transplant Center and Center for Transplantation Sciences, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States. elias.nahel@mgh.harvard.edu
Received: September 21, 2022
Peer-review started: September 21, 2022
First decision: October 24, 2022
Revised: November 7, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: February 18, 2023
Processing time: 147 Days and 13.4 Hours
Core Tip

Core Tip: In this paper, using data from across 25 years, we demonstrate that the adverse effects of hepatitis C infection in donors and/or recipients on kidney transplant outcomes have disappeared since the introduction of direct-acting antiviral agents.