Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Oct 18, 2021; 11(10): 421-431
Published online Oct 18, 2021. doi: 10.5500/wjt.v11.i10.421
Factors predicting futility of liver transplant in elderly recipients: A single-center experience
Cerise Kleb, Muhammad Salman Faisal, Cristiano Quintini, Charles M Miller, K V Narayanan Menon, Jamak Modaresi Esfeh
Cerise Kleb, Muhammad Salman Faisal, Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Cristiano Quintini, Charles M Miller, Department of General Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
K V Narayanan Menon, Jamak Modaresi Esfeh, Department of Gastroenterology & Hepatology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Author contributions: Kleb C designed, performed the research and wrote the paper; Faisal MS contributed to the design of the study and performed analysis of the data; Quintini C, Miller CM and Menon KN helped with critical revisions of the study; Modaresi Esfeh J supervised, helped design the study, made critical revisions to the manuscript and gave final approval.
Institutional review board statement: This study was reviewed and approved by the Cleveland Clinic Foundation Institutional Review Board.
Informed consent statement: This study qualified by a Waiver of Informed Consent as determined by our hospital’s IRB as it was a retrospective study that involved no more than minimal risk to the subjects, could not be reasonably carried out without the waiver, and was not a threat to the rights or welfare of the subjects.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jamak Modaresi Esfeh, MD, Assistant Professor, Department of Gastroenterology & Hepatology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, United States. modarej@ccf.org
Received: February 23, 2021
Peer-review started: February 23, 2021
First decision: May 3, 2021
Revised: May 19, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: October 18, 2021
Processing time: 233 Days and 7 Hours
Core Tip

Core Tip: This was a retrospective study to identify factors associated with futility of liver transplant (LT) in elderly recipients, as well as investigate the risk of certain outcomes such as discharge to facility in elderly LT recipients. Diastolic congestive heart failure (CHF) was found to be a predictor of futility of LT in elderly recipients (P = 0.001). Elderly patients also had nearly twice the risk of being discharged to a facility and had decreased survival at one year. Diastolic CHF may be an important comorbidity for liver transplant committees to consider when deciding whether or not to list elderly patients.