Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Transplant. Jun 18, 2023; 13(4): 157-168
Published online Jun 18, 2023. doi: 10.5500/wjt.v13.i4.157
Is peri-transplant blood transfusion associated with worse transplant outcomes? A retrospective study
Muhammad A Bukhari, Faisal K Alhomayani, Hala S Al Eid, Najla K Al-Malki, Mutlaq Eidah Alotaibi, Mohamed A Hussein, Zainab N Habibullah
Muhammad A Bukhari, Zainab N Habibullah, Multi-organ Transplantation Center, King Abdullah Medical City, Makkah 29123, Saudi Arabia
Faisal K Alhomayani, Department of Internal Medicine, College of Medicine, Taif University, Taif 23611, Saudi Arabia
Hala S Al Eid, Department of Pharmacy, Alhada Armed Forces Hospital, Taif 29123, Saudi Arabia
Najla K Al-Malki, Mutlaq Eidah Alotaibi, Mohamed A Hussein, Department of Nephrology and Transplantation, Alhada Armed Forces Hospital, Taif 29123, Saudi Arabia
Author contributions: All the co-authors contributed in data collection, writing, editing, literature review and designing the study.
Institutional review board statement: Approved by the hospital's IRB at AL-Hada Armed Forces Hospital, No. REC 2023-719.
Informed consent statement: Signed informed consent wasn’t required for this manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Muhammad A Bukhari, MD, Attending Doctor, Multi-organ Transplantation Center, King Abdullah Medical City, Third Ring Road, Makkah 29123, Saudi Arabia. bukhary5354@hotmail.com
Received: March 17, 2023
Peer-review started: March 17, 2023
First decision: April 13, 2023
Revised: April 18, 2023
Accepted: May 4, 2023
Article in press: May 4, 2023
Published online: June 18, 2023
Processing time: 90 Days and 15.5 Hours
ARTICLE HIGHLIGHTS
Research background

Blood transfusion is common during the peri-transplantation period. The incidence of immunological reactions to blood transfusion after kidney transplantation and their consequences on graft outcomes have not been extensively studied.

Research motivation

Blood transfusion during the peri-transplantation period is very common and its safety need to be studied.

Research objectives

To examine the risk of graft rejection and loss in patients who received blood transfusion in the immediate peri-transplantation period.

Research methods

A retrospective cohort study of 105 kidney recipients who received leukodepleted blood transfusions at our center between January 2017 and March 2020.

Research results

Of 105 kidney recipients were divided into transfusion (n = 54) and non-transfusion (n = 51) groups. There were no differences between the two groups in terms of rejection rates, graft loss, or death. There was no significant difference in creatinine level progression between the two groups. A high number of transfused packed red blood cells was significantly associated with increased creatinine levels at the end of the study.

Research conclusions

Leukodepleted blood transfusion was not associated with a higher risk of rejection, graft loss, or death in kidney transplant recipients.

Research perspectives

Leukodepleted blood transfusion in the peri-transplantation period is likely safe.