Heath RD, Ertem F, Romana BS, Ibdah JA, Tahan V. Hepatocyte transplantation: Consider infusion before incision. World J Transplant 2017; 7(6): 317-323 [PMID: 29312860 DOI: 10.5500/wjt.v7.i6.317]
Corresponding Author of This Article
Veysel Tahan, MD, FACP, FACG, FESBGH, Associate Professor, Division of Gastroenterology and Hepatology, University of Missouri, 1 Hospital Dr, Columbia, MO 65212, United States. tahanv@health.missouri.edu
Research Domain of This Article
Transplantation
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Transplant. Dec 24, 2017; 7(6): 317-323 Published online Dec 24, 2017. doi: 10.5500/wjt.v7.i6.317
Hepatocyte transplantation: Consider infusion before incision
Ryan D Heath, Furkan Ertem, Bhupinder S Romana, Jamal A Ibdah, Veysel Tahan
Ryan D Heath, Bhupinder S Romana, Jamal A Ibdah, Veysel Tahan, Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO 65212, United States
Furkan Ertem, Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260, United States
Author contributions: All authors contributed to the acquisition of data, writing, and revision of this manuscript.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare. All authors of this article declare that there is no conflicting interests (including but not limited to commercial, personal, political, intellectual or religious interests) that are related to the work submitted for consideration of publication. The statement of “No conflict of interest” file is signed by each author and attached.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Veysel Tahan, MD, FACP, FACG, FESBGH, Associate Professor, Division of Gastroenterology and Hepatology, University of Missouri, 1 Hospital Dr, Columbia, MO 65212, United States. tahanv@health.missouri.edu
Telephone: +1-573-8846044 Fax: +1-573-8844595
Received: October 28, 2017 Peer-review started: October 29, 2017 First decision: November 20, 2017 Revised: November 27, 2017 Accepted: December 5, 2017 Article in press: December 6, 2017 Published online: December 24, 2017 Processing time: 54 Days and 16.6 Hours
Abstract
Human hepatocyte transplantation is undergoing study as a bridge, or even alternative, to orthotopic liver transplantation (OLT). This technique has undergone multiple developments over the past thirty years in terms of mode of delivery, source and preparation of cell cultures, monitoring of graft function, and use of immunosuppression. Further refinements and improvements in these techniques will likely allow improved graft survival and function, granting patients higher yield from this technique and potentially significantly delaying need for OLT.
Core tip: Further human studies involving humans are needed, however, the current collectively suggest progress in terms of improved effectiveness of human hepatocyte transplantation (HTx). With improvements in optimizing delivery technique and assessing proper recipients of livers, monitoring graft function, as well as recognizing and treating graft rejection, HTx may be able to be used more widely in metabolic liver disease and potentially delay necessity of orthotopic liver transplantation.
